The RAD51 protein has been shown to participate in homologous recombination by promoting ATP-dependent homologous pairing and strand transfer reactions. In the present study, we have investigated the possible involvement of RAD51 in non-homologous recombination. We demonstrate that overexpression of CgRAD51 enhances the frequency of spontaneous non-homologous recombination in the hprt gene of C...

When can surgery on a null-homologous knot K in rational homology sphere produce non-separating sphere? We use Heegaard Floer to give sufficient conditions for be unknotted. also discuss some applications cobordism, concordance, and Mazur manifolds.

Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of ho­mogenate the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true disease nervous system.
 Materials methods: studies were conducted on white nonlinear rats. To induce experimental aller­gic (EAE), homologous brain homogenates was used, which leads a...

Since the report of first cases pneumonia caused by SARS-CoV-2 in December 2019, COVID-19 has become a pandemic and is globally overwhelming healthcare systems. The symptoms vary from asymptomatic infection to severe complicated with acute respiratory distress syndrome (ARDS) multiple organ failure leading death. estimated case-fatality rate among infected patients Wuhan, city where case appear...

We investigate the cause of spatial superexchange anisotropy in a family copper-based, quasi-two-dimensional materials with very similar geometries. The compounds this differ mainly their inter-layer separation but they have different magnetic interactions, even within basal plane. use density functional theory and Wannier functions to parameterize two complimentary tight-binding models show th...

ABSTRACT The DNA damage response (DDR) is the signaling cascade that recognizes double-strand breaks (DSBs) and promotes their resolution via repair pathways of non-homologous end joining (NHEJ) or homologous recombination (HR). We others have shown DDR activation requires DROSHA; however, whether DROSHA exerts its functions by associating with sites, what controls recruitment, how influences r...

In mammalian cells, the repair of DNA double-strand breaks (DSBs) occurs by both homologous and non-homologous mechanisms. Indirect evidence, including that from gene targeting and random integration experiments, had suggested that non-homologous mechanisms were significantly more frequent than homologous ones. However, more recent experiments indicate that homologous recombination is also a pr...