Backgound/Objectives Urolithins (UROs) are the metabolites derived from gut microbial action on ellagitannins and ellagic acid-rich foods. Following their absorption in intestine, UROs transported through systemic circulation to various tissues where they can express biological function as antimicrobial, anti-inflammatory, anticancer agents. In addition blood plasma, be found glucuronide sulfat...

This study was carried out to evaluate the effect of onion extract on growth performance, carcass characteristics and some blood metabolites in Ross and Cobb broiler chickens. One hundred sixty, 1-d-old broiler chickens (mean initial weight: 36.5 ± 1 g) of male sex (Ross-308 and Cobb) were randomly conducted as randomized complete design with 4 treatment and 4 replication. The experimental grou...

We examined the effect on some clinical chemical assays of adding chlordiazepoxide or its two metabolites, the lactam and the N-desmethylchlordiazepoxide, to serum or urine. We also examined the effect on urinary steroid values of administering the drug for as long as 20 days. The drug, in 10-fold the expected concentrations in blood, or its metabohites, in 200-fold the expected Concentration i...

The chemical nature of the non-specific hyaluronidase inhibitor normally present in blood serum has not been elucidated, but quinoid and hydroquinoid compounds have been found to be most effective inhibitors of the depolymerization of hyaluronic acid by hyaluronidase in vitro (1, 2). Other researches have suggested that intermediate metabolites of reduced or oxidized quinoid type may appear in ...

The present study aimed to investigate the serum metabolomic profiles in genetically modified cows carrying and expressing human lactalbumin α (LALBA) and non‑LALBA cows, and identify altered metabolic characteristics following the genetic modification. Serum biochemistry indexes were measured according to protocols recommended by International Federation of Clinical Chemistry. The metabolomic ...

ferula (ferula assafetida) is a perennial plant which belongs to umbelliferea family is grow in a wide range of arid and semi-arid regions in iran. ferulla assafetida contains compounds including coumarins and sesquiterpens that has been traditionally used to treat diseases such as nervous disorders, asthma, gastrointestinal disease and epilepsy.. effects of asafetida gum extract on blood param...

The purpose of the study was to evaluate the effect of retained fetal membranes (RFM) on serum minerals and energy- and protein-related metabolites in dairy cows at a herd with a recent history of fatty liver syndrome. Forty-seven multiparous Holstein cows were selected during transition period. Nine cows had RFM longer than 24 h after calving. Blood samples were obtained on prepartum days 21 a...

Amifostine is one of the cytoprotective drugs used during anticancer therapy. Amifostine as a thiol compound possesses antioxidant properties and protects only healthy cells against damage, mainly by scavenging reactivity oxygen species, competing with oxygen to prevent oxygen radical interactions with DNA, and promoting cell repair through hydrogen donation to reactive oxygen species. The aim ...

The in vivo metabolism of 2,3,3',4,4'-pentachlorobiphenyl (CB105) was studied in hamsters and the effect of cytochrome P450 inducers, phenobarbital (PB) and 3-methylcholanthrene (MC) on its metabolism was compared to rats. After administration of CB105 intraperitoneally at a dose of 3 mg/body, four metabolites, named M-1, M-2, M-3 and M-4, were detected in 5 days-feces of all groups and the for...

BACKGROUND Soil Transmitted Helminth (STH) infections negatively impact physical and mental development in human populations. Current WHO guidelines recommend morbidity control of these infections through mass drug administration (MDA) using albendazole (ABZ) or mebendazole. Despite major reductions in STH associated morbidity globally, not all programs have demonstrated the expected impact on ...