Extracellular pH (pHe) of tumor cells is characteristic microenvironment (TME). Acidic TME impairs the responses tumors to some anti-cancer chemotherapies. In this study, we showed that daily oral dosing sodium potassium citrate (K/Na citrate) increased blood HCO3− concentrations, corresponding increase concentrations and pHs in urine, neutralized pHe. Neutralization acidic by alkaline substanc...

Background: The heterogeneous breast cancer is the most common cause of cancer-related mortality. Obesity defined by BMI is known as a major risk factor for breast cancer. Objective: The purpose of this study was to explore the role of obesity related-polymorphisms rs9939609 FTO and rs17782313 MC4R in breast cancer development. Materials and Methods: We obtained matched peripheral blood, serum ...

    Background: Iron is one of the nutrients that has recently received considerable attention because of its dual role in the incidence of breast cancer. The present study aimed at comparing hematological parameters, iron levels, and oxidative stress in women with and without breast cancer.    Methods: The participants in this case-control study were 55 women, of whom...

Intra-tumor bacteria promote tumor growth and inactivate cancer-chemotherapeutics, causing poor treatment prognoses. Combined administration of cancer-chemotherapeutics antibiotics may disturb the oral intestinal microflora in critically-ill patients. To establish intra-tumor co-delivery antibiotics, gemcitabine ciprofloxacin are loaded so-called “self-targeting”, highly blood-compatible, synth...

Research over the past few decades has focused on use of functional ingredients such as an active lifestyle and proper diet a treatment for many diseases in world. Recent studies have shown variety health benefits red beets their antioxidant, anti-inflammatory, anti-cancer, blood pressure fat reduction, anti-diabetic, anti-obesity effects. This review article examines effects exercise beet cons...