Self-assembled nano-micelles of amphiphilic polymers represent a novel anticancer drug delivery system. However, their full clinical utilization remains challenging because the quantitative structure-property relationship (QSPR) between the polymer structure and the efficacy of micelles as a drug carrier is poorly understood. Here, we developed a series of QSPR models to account for the drug lo...

A fluorescence-based method has been developed to detect the structural changes that occur in micelle systems. The sensitivity of fluorescein isothiocyanate (FITC) has been evaluated for (i) detecting the micellization of cetyltrimethyl ammonium bromide (CTAB) and (ii) probing the concentration dependent aggregation, leading to microstructural changes that occur within CTAB micelles. The critic...

The blood-brain barrier (BBB) is formed by the brain microvascular endothelium, and the unique transport properties of the BBB are derived from tissue-specific gene expression within this cell. The current studies developed a gene microarray approach specific for the BBB by purifying the initial mRNA from isolated rat brain capillaries to generate tester cDNA. A polymerase chain reaction-based ...

Polymeric micelles obtained from the self-assembly of amphiphilic block copolymers are probably one of the most common drug delivery carriers among polymeric nanoparticles.1–4 The rise of highly controlled polymerization techniques, especially processes such as ATRP5 and RAFT,6 has led to an extraordinary surge of new types of block copolymers fit for biomedical applications. Facile control ove...

The existence of a barrier between the central nervous system (CNS) and the systemic circulation has been described over one hundred years ago. Since the discovery that this barrier was instigated by the barrier properties of the brain endothelial cells, research has focused on the identification of pathways how the brain endothelial cells are instructed to form the highly specialized blood-bra...

Objective(s):Protective effects of diuretics, particularly of hydrochlorothiazide (HCT), for the development of seizure attacksepilepsy have been described in vivo. However, itsthe mechanism of action of HCT is unknownneeds to be elucidated. Materials and Methods: Extracellular field potentials were recorded from the CA1- and CA3-subfields of the hippocampus of rats. Epileptiform discharges wer...

To systematically investigate the relationship among surface charge, PEG chain length, and nano-bio interactions of dendron-based micelles (DMs), a series of PEGylated DMs with various end groups (-NH2, -Ac, and -COOH) and PEG chain lengths (600 and 2000 g/mol) are prepared and tested in vitro. The DMs with longer PEG chains (DM2K) do not interact with cells despite their positively charged sur...

BACKGROUND The pan-histone deacetylase inhibitor panobinostat is a potential therapy for malignant glioma, but it is water insoluble and does not cross the blood-brain barrier when administered systemically. In this article, we describe the in vitro and in vivo efficacy of a novel water-soluble nano-micellar formulation of panobinostat designed for administration by convection enhanced delivery...

Polymeric micelles are nanoscale core-shell structures formed by amphiphilic (block or graft) copolymers, that can self-aggregate in an aqueous medium. PMs characterized small size, spherical shape, lower critical micellar concentration, which gave higher
 stability for over conventional surfactant micelles. The core/shell structure permits polymeric micelle to entrap poor soluble drugs an...