How can a therapy be targeted to cancer if the target is in every normal cell? Because proteasomes are found in all nucleated as well as anucleated cells, it could be argued that this target is even less cancer-specific than that of conventional DNA-damaging chemotherapy. However, proteasome inhibitors clearly have made an impact in the treatment of many types of cancer and none bigger than in ...

Blocked mutants of Micromonospora echinospora defective in the production of the potent antitumor agent calicheamicin are described. Analysis of intermediates produced by blocked mutants indicates a branched biosynthetic pathway. Mutants that produced some, but not all, calicheamicin forms are also described.

introduction: renin angiotensin system has an important role in blood pressure and renal functions. active angiotensin-converting enzyme 2 converts angiotensin i into angiotensin-(1-7) which is a vasodilator hormone and interacts with nitric oxide changes as well as other angiotensin ii receptors. in this study we evaluated the role of mas receptor antagonist (a779) and renal perfusion pressure...

this study aimed at investigating the effect of blocked, incremental systematic and random contextual interferences on acquisition, retention and transfer of volleyball skills based on changes in a generalized motor program. in fact, this study was conducted to answer this question that whether regular increment of contextual interference level is more effective on learning volleyball service s...

In this paper, a new structure for cascade multilevel inverter is presented which consists of a series connection of several sub-multilevel units. Each sub-multilevel unit comprises of eight unidirectional switches, two bidirectional switches, and six DC voltage sources. For the proposed cascade topology, two algorithms are presented to produce all possible levels at the output voltage waveform...

Preprocessing has proven important in enabling efficient Boolean satisfiability (SAT) solving. For many real application scenarios of SAT it is important to be able to extract a full satisfying assignment for original SAT instances from a satisfying assignment for the instances after preprocessing. We show how such full solutions can be efficiently reconstructed from solutions to the conjunctiv...

We present partitioned (blocked) algorithms for reducing a symmetric matrix to a tridiagonal form, with partial pivoting. That is, the algorithms compute a factorization PAP = LTL where P is a permutation matrix, L is lower triangular with a unit diagonal, and T is symmetric and tridiagonal. The algorithms are based on the column-by-column methods of Parlett and Reid and of Aasen. Our implement...

The problem of multilocus linkage analysis is expressed as a graphical model, making explicit a previously implicit connection, and recent developments in the field are described in this context. A novel application of blocked Gibbs sampling for Bayesian networks is developed to generate inheritance matrices from an irreducible Markov chain. This is used as the basis for reconstruction of histo...