Introduction . Bleomycin is a cytotoxic antibiotic that used as sclerosing agent for sclerotherapy of vascular anomalies. characterized by complications: nausea, vomiting, fever, the development allergies/anaphylaxis, skin discoloration (hyperpigmentation), damage to lung tissue. Aim To study frequency hyperpigmentation after administration bleomycin malformations with slow flow characteristics...

PURPOSE Photochemical internalization is under development for improving macromolecular therapy by inducing photochemical damage to endocytic vesicles. This damage leads to the release of therapeutic macromolecules entrapped in endocytic vesicles into the cytosol. The macromolecules may in this way be able to interact with therapeutic targets instead of being degraded by lysosomal hydrolases. B...

BACKGROUND Pulmonary fibrotic diseases induce significant morbidity and mortality, for which there are limited therapeutic options available. Rac2, a ras-related guanosine triphosphatase expressed mainly in hematopoietic cells, is a crucial molecule regulating a diversity of mast cell, macrophage, and neutrophil functions. All these cell types have been implicated in the development of pulmonar...

Background-Increased production of transforming growth factor p (TGF-/J) seems to have an important role in the pathophysiology of bleomycin induced lung fibrosis. This is attributed to the ability of TGF-/) to stimulate infiltration of inflammatory cells and promote synthesis of connective tissue, leading to collagen deposition. Methods-The study was designed to evaluate the antifibrotic poten...

conclusions atorvastatin may play a protective role in pulmonary fibrosis, with its effects mediated via the station’s antioxidant and anti-inflammatory properties. atorvastatin may be a potential agent for the treatment of lung injury and fibrosis. background pulmonary fibrosis is an idiopathic and chronic inflammatory interstitial lung disease, with a negligible response to available medical t...

BACKGROUND Increased production of transforming growth factor beta (TGF-beta) seems to have an important role in the pathophysiology of bleomycin induced lung fibrosis. This is attributed to the ability of TGF-beta to stimulate infiltration of inflammatory cells and promote synthesis of connective tissue, leading to collagen deposition. METHODS The study was designed to evaluate the antifibro...

Following treatment with bleomycin- and cisplatin-containing chemotherapy, testicular cancer patients frequently develop vascular complications, which may result from damage to endothelial cells. Understanding bleomycin- and cisplatin-induced endothelial alterations may help to develop strategies to prevent or reduce vascular toxicity. The effects of bleomycin and cisplatin on proliferation and...

BACKGROUND Bleomycin is a cytotoxic drug used in treatment of Germ Cell Tumours (GCTs) and is associated with pulmonary toxicity. Bleomycin pulmonary toxicity (BPT) manifests predominantly as pulmonary fibrosis, organising pneumonia (OP) or Nonspecific Interstitial Pneumonitis (NSIP). Our objectives were to determine the incidence of BPT, describe the common HRCT patterns of pulmonary toxicity ...