Introduction. It is a consensus that the postoperative cognitive function is impaired in elderly patients after general anaesthesia, and such category patient takes more time to recover. Xenon is a noble gas with anesthetic properties mediated by antagonism of N-methyl-D-aspartate receptors. With a minimum alveolar concentration of 0.63, xenon is intended for maintaining hypnosis with 30% oxyge...

BACKGROUND Cocaine-dependent individuals (CDI) display increased impulsivity. However, despite its multifactorial nature most studies in CDI have treated impulsivity monolithically. Moreover, the impact of attention-deficit/hyperactivity disorder (ADHD) has often not been taken into account. This study investigates whether CDI with ADHD (CDI+ADHD) differ from CDI without an ADHD diagnosis and h...

BACKGROUND Intraoperative dexmedetomidine may decrease postoperative emergence agitation in elderly patients due to its sedative effect. In this study, we evaluated the effect of adjuvant dexmedetomidine on smooth emergence from anaesthesia after orthopaedic surgery in elderly patients. METHODS A total 115 patients (ASA I-II, aged over 65 years) were randomly allocated into four groups. Anaes...

Background: Mechanical ventilation and sedation are inextricably linked components of critical care that represent, what we do for the patients during their vulnerable course in ICU. Aims: The aim of the present study is to evaluate the use of BIS for monitoring sedation in mechanically ventilated ICU patients and correlation of BIS with Sedation Agitation Scale. Settings and Design: Prospectiv...

Daniel I. Sessler, MD† BACKGROUND: In previous studies, we showed that failure to respond to automated responsiveness monitor (ARM) precedes potentially serious sedationrelated adversities associated with loss of responsiveness, and that the ARM was not susceptible to false-positive responses. It remains unknown, however, whether loss and return of response to the ARM occur at similar sedation ...

Bis(chlorotetrylene)s of Si, Ge, and Sn have been synthetically realized starting from the backbone-bridged bis(amidine) 1. Double deprotonation 1 subsequent reaction with trichlorosilane affords bis(dichorosilane) 2, which is converted to respective bis(chlorosilylene) 3 by dehydrochlorination using lithium bis(trimethylsilyl)amide. The related bis(chlorogermylene) 4 bis(chlorostannylene) 5 ar...