A myriad of orthopaedic injuries require surgical fixation of torn connective tissue to an osseous insertion site with either direct repair or reconstruction with a soft-tissue graft. Numerous factors influence the strength of a soft-tissue-to-bone fixation construct, including tissue quality, implant strength, contact area and pressure, and tensioning. Each fixation technique differs with resp...

A mutation in LRP5 (low-density lipoprotein receptor-related protein 5) has been shown to increase bone mass and density in humans and animals. Transgenic mice expressing the LRP5 mutation (G171V) demonstrate an increase in bone mass as compared to non-transgenic (NTG) littermates. This study evaluated LRP5 gene and gender-related influences on the structural and biomechanical strength properti...

Our goal was to develop a novel technique for inducing Achilles tendinopathy in animal models which more accurately represents the progressive histological and biomechanical characteristic of chronic Achilles tendinopathy in humans. In this animal research study, forty-five rabbits were randomly assigned to three groups and given bilateral Achilles injections. Low dose (LD group) (n = 18) under...

The objective of this study was to evaluate the influences of enamel shape and bracket base configuration on shear bond strength from a biomechanical point of view. To this end, shear bond test and stress analysis using finite element method (FEM) were performed. Results obtained from both tests were then comprehensively investigated. Maxillary incisors were prepared for plane specimens, while ...

We examined a behavioral mechanism of how increases in leg strength improve healthy old adults' gait speed. Leg press strength training improved maximal leg press load 40% (p = 0.001) and isometric strength in 5 group of leg muscles 32% (p = 0.001) in a randomly allocated intervention group of healthy old adults (age 74, n = 15) but not in no-exercise control group (age 74, n = 8). Gait speed i...

We performed a biomechanical study to compare the augmentation of isolated fractured vertebral bodies using two different bone tamps. Compression fractures were created in 21 vertebral bodies harvested from red deer after determining their initial strength and stiffness, which was then assessed after standardised bipedicular vertebral augmentation using a balloon or an expandable polymer bone t...

In an attempt to understand the relationship between quasi-static and dynamic test results, repeatable, dynamic rollover tests were conducted on production vehicles to determine intrusion and intrusion velocities using the Jordan Rollover System (JRS). These tests included complete production vehicles and body bucks at reduced weight, to vary the roof strength-to-weight ratio. Data from these t...

The purpose of this study is to evaluate the biomechanical properties of stainless steel and bioabsorbable screw fixation of the clavicle to the base of the coracoid. Seven matched pairs of fresh frozen shoulders were prepared by removing all soft tissue except the acromioclavicular and coracoclavicular ligament complexes. The shoulders were randomly selected and fixed with 4.5-mm stainless ste...

BACKGROUND As articular cartilage is unable to repair itself, there is a tremendous clinical need for a tissue engineered replacement tissue. Current tissue engineering efforts using the self-assembly process have demonstrated promising results, but the biomechanical properties remain at roughly 50% of native tissue. METHODOLOGY/PRINCIPAL FINDINGS The objective of this study was to determine ...