Cinchophen (I) was synthesized from pyruvic acid, aniline and benzaldehyde by Doebner synthesis. Cinchophen acid chloride (II) was synthesised from cinchophen and oxalyl chloride by acylation reaction. The 2phenylquinoline-4-carboxylic acid amide (III) was synthesized from acid chloride and ammonia by simple reaction. The 2-phenylquinoline-4-carboxylic acid amine (IV) was synthesized from cinch...

The growth method of comparing the nutritive value of proteins, namely the estimation of protein efficiency ratio (P.E.R.) has long been popular because of its simplicity despite its well-known drawbacks (Mitchell, 1944). Among the more serious disadvantages of this method are: (a) no allowance is made for maintenance requirements of the test animal, ( 6 ) the result varies with food intake, an...

1,25-dihydroxyvitamin D3 (1,25D), a steroid hormone which regulates calcium/phosphate homeostasis, has a broad spectrum of anti-cancer activities, including differentiation of acute myeloid leukemia (AML) cells. In order to avoid undesirable side effects such as hypercalcemia, low-calcemic analogues should be produced for therapeutic purposes. In this paper, we describe biological activities of...

Condensation of the corresponding chlorides of some substituted pyrazine-2-carboxylic acids (pyrazine-2-carboxylic acid, 6-chloropyrazine-2-carboxylic acid, 5-tert-butylpyrazine-2-carboxylic acid or 5-tert-butyl-6-chloropyrazine-2-carboxylic acid) with various ring-substituted aminothiazoles or anilines yielded a series of amides. The syntheses, analytical and spectroscopic data of thirty newly...

Nine derivatives of three natural diarylheptanoids, curcumin, demethoxycurcumin and bisdemethoxycurcumin, were prepared. Their antioxidant, free radical scavenging, nitric oxide (NO) inhibitory and cytotoxic activities were evaluated and compared with those of the respective natural compounds. Curcumin (1), demethoxycurcumin (2), demethyldemethoxy-curcumin (C3), diacetyldemethoxycurcumin (AC2) ...

Various neoglycosphingolipids were efficiently synthesized in a one-step reaction by the coupling of free sugars with an N-alkylaminooxy-functionalized ceramide analogue. The bioactivity studies demonstrated that most of these compounds could upregulate the expression of matrix metalloproteinase-9 (MMP-9, extracellular matrix proteins associated with tumor migration) in murine melanoma B16 cell...

Four derivatives of benzotriazole-5-carboxylic acid were synthesized as potential UV-light dependent DNA cleaving agent. The effect of these compounds on phiX174 RF1 phage DNA and pBR322 plasmid DNA was investigated with and without UV exposure. It has been found that the two compounds exert the influence on topological forms of DNA.

Protocols for selective acetylation of the hydroxyl groups of ginkgolide C have been developed. These acetylations have given rise to various ginkgolide C acetates and iso-ginkgolide C acetates, the latter having a rearranged skeleton resulting from translactonization. These acetyl derivatives, as well as ginkgolides A and B acetates have been investigated for their ability to bind to a cloned ...

This study describe the organic synthesis of 2-iodobenzamido (2-N-nitrobenzen-5, 6, 7, 8 tetrahydrobenzothieno [2, 3d]) pyrimidine -4-(3H) one as an example for some pyrimidine derivative used a new series of as potential cancer chemotherapeutic agents. The precursor derivative is α-(2-iodobenzamido)-β (4-nitrophenyl)-N[3-ethoxy-carbonyl-4, 5, 6, 7-tetrahydrobenzothiophen-2-l] acrylic acid amid...

On the forefront of recent HPC innovations are Field Programmable Gate Arrays (FPGA), which promise to accelerate calculations by one or more orders of magnitude. The performance of two Cray XD1 systems with Virtex-II Pro 50 and Virtex-4 LX160 FPGAs, were evaluated using a computational biological human genome comparisons program. This paper describes scalable, parallel, FPGA-accelerated result...