The Bicoid (Bcd) protein gradient is generally believed to be established in pre-blastoderm Drosophila embryos by the diffusion of Bcd protein after translation of maternal mRNA, which serves as a strictly localized source of Bcd at the anterior pole. However, we previously published evidence that the Bcd gradient is preceded by a bcd mRNA gradient. Here, we have revisited and extended this obs...

An investigation was made of azaserine entry into cells of a sensitive and resistant line of the plasma-cell neoplasm 70429. Transport experiments determined (a) the initial velocity of concentrative uptake in the first 1 or 2 minutes of exposure to the compound, (6) the total kinetics of uptake over 30-minute to 90-minute periods, and (c) the dependence of steady-state uptake on the extracellu...

BACKGROUND Among Belgian adolescents active transport (AT) is a common physical activity (PA) behavior. Preliminary evidence suggests that AT can be an important opportunity for increasing adolescents' daily PA levels. To inform interventions, predictors of this PA behavior need to be further explored. Therefore, in the perspective of the ecological models this study aimed (a) to investigate th...

Active transportation to and from school (ATS) is a viable strategy to help increase physical activity among youth. ATS can be challenging because initiatives require transdisciplinary collaboration, are influenced by the built environment and are affected by numerous policies. The purpose of this study is to identify policies and factors that influence ATS initiatives. Nine elementary schools ...

The biological processes in elongated organelles of living cells are often regulated by molecular motor transport. We determined spatial distributions of motors in such organelles, corresponding to a basic scenario when motors only walk along the substrate, bind, unbind, and diffuse. We developed a mean-field model, which quantitatively reproduces elaborate stochastic simulation results as well...

Supermassive black holes can be seen as an agent of galaxy transformation. In particular, a supermassive black hole can cause a triaxial galaxy to evolve toward axisymmetry by inducing chaos in centrophilic orbit families. This is one way in which a single supermassive black hole can induce large-scale changes in the structure of its host galaxy – changes on scales far larger than the Schwarzsc...

BACKGROUND As the date for the introduction of biosimilars in the United States approaches, questions remain regarding the naming, coding, and approval process for these agents that will need to be carefully considered. OBJECTIVES To (a) ascertain pharmacists' awareness of and comfort level with biosimilars and (b) determine the impact of identical or different nonproprietary names on pharmac...

BACKGROUND Evidence is mounting to suggest a causal relationship between the built environment and people's physical activity behaviours, particularly active transport. The evidence base has been hindered to date by restricted consideration of cost and economic factors associated with built environment interventions, investigation of socioeconomic or ethnic differences in intervention effects, ...

OBJECTIVE This study examines associations between area deprivation and perceived neighbourhood safety with active transport to school among preadolescents living in urban Quebec. METHODS A sample of 809 preadolescents aged 9 to 13 years and one each of their parents living in urban Quebec were recruited by a polling firm for a telephone interview about the Opération WIXX multimedia communica...