نتایج جستجو برای: biochemical reactions
تعداد نتایج: 294549 فیلتر نتایج به سال:
The sulfur amino acid homocysteine has recently been addressed as marker for vessel damaging and atherosclerotic dispositions. The atherogenic index has been correlated with the one of cholesterol and is significantly higher in cholesterinemic as compared to normal lipidemic persons. In the present communication biochemical model reactions are presented indicating the prooxidative activity of h...
Genome-scale metabolic network reconstructions are now routinely used in the study of metabolic pathways, their evolution and design. The development of such reconstructions involves the integration of information on reactions and metabolites from the scientific literature as well as public databases and existing genome-scale metabolic models. The reconciliation of discrepancies between data fr...
Rhea (http://www.rhea-db.org) is a comprehensive and non-redundant resource of expert-curated biochemical reactions designed for the functional annotation of enzymes and the description of metabolic networks. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions, using entities from the ...
This paper presents a stochastic modelling framework based on stochastic automata networks (SANs) for the analysis of complex biochemical reaction networks. Our approach takes into account the discrete character of quantities of components (i.e. the individual populations of the involved chemical species) and the inherent probabilistic nature of microscopic molecular collisions. Moreover, as fo...
Sensitivity analysis of biochemical reactions aims at quantifying the dependence of the reaction dynamics on the reaction rates. The computation of the parameter sensitivities poses many computational challenges when taking stochastic noise into account. This paper proposes a new efficient finite difference method for computing parameter sensitivities of biochemical reactions. We employ propens...
Parameter estimation is very important for the analysis of models in systems biology. Computational modeling is a central approach in systems biology, for studying increasingly complex biochemical systems. Progress in experimental techniques, e.g. the possibility to measure small numbers of molecules in single cells [1], highlights the need for stochastic modeling approaches. Simulation methods...
RING domains act in a variety of unrelated biochemical reactions, with many of these domains forming key parts of supramolecular assemblies in cells. Here, we observe that purified RINGs from a variety of functionally unrelated proteins, including promyelocytic leukemia protein, KAP-1TIF1beta, Z, Mel18, breast cancer susceptibility gene product 1 (BRCA1), and BRCA1-associated RING domain (BARD1...
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