A new hirsutane derivative, phellodonic acid (1), has been isolated from fermentations of Phellodon melaleucus strain 87113. Its structure was elucidated by spectroscopic methods. The compound exhibits antibiotic activities towards bacteria and fungi. 1 is the first bioactive metabolite from cultures of a species belonging to the family Thelephoraceae.

A new method for the synthesis of 1H-indazoles from readily available N-tosylhydrazones and nitroaromatic compounds has been developed. This transformation occurs under transition-metal-free conditions and shows a wide substrate scope. The method has been successfully applied to the formal synthesis of a bioactive compound, WAY-169916.

Isolation of a number of bioactive compounds from medicinal plants such as acetylcholinesterase inhibiting steroidal alkaloids, homomoenjodaramine and moenjodaramine from Buxus hyrcana, anti-epileptic terpenoids delphadienones I and II from Delphinium denudatum, and potent leishmanicidal compound ajoene from Allium sativum have been achieved through bioactivity-guided isolation.

the genus rhodococcus is gram positive bacterium which was classified into the family of nocardiaceae. the organism can be isolates from different sources, with capability to degrade diverse types of pollutant. nowadays, scientists reported a few secondary metabolites which are produced by rhodococci. hence, the present study tried to isolate rhodococci from different soil samples with the capa...

Representing the 3D structures of ligands in virtual screenings via multi-conformer ensembles can be computationally intensive, especially for compounds with a large number of rotatable bonds. Thus, reducing the size of multi-conformer databases and the number of query conformers, while simultaneously reproducing the bioactive conformer with good accuracy, is of crucial interest. While clusteri...

BACKGROUND Gymnema sylvestre is an ethno-pharmacologically important medicinal plant used in many polyherbal formulations for its potential health benefits. Silver nanoparticles (SNPs) were biofunctionalized using aqueous leaf extracts of G. sylvestre. The anticancer properties of the bioactive compounds and the biofunctionalized SNPs were compared using the HT29 human adenoma colon cancer cell...

Molecular docking is a bioinformatics tool used to study and analyse ligand receptor interactions. This helps in identifying the receptors (molecular targets) for different ligands. Using these technologies, compound isolation and drug discovery from herbals is achieved. Herbs are widely used in treatment of various ailments from time immemorial. Phytochemists and drug developers are now intere...

Lactobacillus plantarum has potential applications and health benefits. This comprehensive literature review highlights the probiotic properties of L. its ability to withstand adverse conditions adhere intestinal epithelium. It immense in food industry, focusing on fermentation, preservation, bioactive compound production. Furthermore, impact human health, including role modulating gut microbio...

Microbial secondary metabolites represent a rich, chemically-diverse source of bioactive compounds that have been exploited for applications in human medicine, agriculture, and industry [1-3]. Natural product fermentation bioprocesses have remained an important tool in efforts to acquire chemical diversity in bioactive compound libraries for lead generation [4]. In recent years, natural product...

Marine Streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. The cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (DMEHE) from marine derived actinomycete Streptomyces sp. VITSJK8 was investigated against mouse embryonic fi...