The present study aimed to investigate the properties of a promising bone scaffold for bone repair, which consisted of a novel composite of adipose-derived stem cells (ADSCs) attached to a porous β-tricalcium phosphate (β-TCP) scaffold with platelet-rich plasma (PRP). The β-TCP powder was synthesized and its composition was determined using X-ray diffraction and Fourier transform infrared spect...

A label-free electrochemical biosensor has been developed using zinc oxide nanoflowers (ZnONFs) for the detection of uric acid concentration in human blood serum. ZnONFs have synthesized by a hydrothermal process and characterized with several techniques such as ultraviolet–visible (UV–Vis) spectroscopy, Fourier transform infrared spectroscopy (FTIR) studies, X-ray diffraction (XRD) study, Rama...

Collagen and gelatin is widely used as bio-polymer materials and medical materials. Currently, the direction is more and more clear that collagen-like peptide produced by chemical synthesis, and recombinant collagen and gelatin produced in various expression system constructed by gene engineering technique substitute for these products prepared by traditional methods. Based on the characteristi...

We report a facile approach to the construction of patterns of biomolecules based on polymeric self-assembled monolayers (pSAMs) that possess dual functions: "bio-reactive (post-functionalizable)" and "bio-inert (anti-biofouling)" properties. To prepare pSAMs on Si/SiO2 wafers were synthesized new random copolymers by radical polymerization of poly(ethylene glycol) methyl ether methacrylate (PE...

Composite materials based on a titanium support and a thin, alginate hydrogel could be used in bone tissue engineering as a scaffold material that provides biologically active molecules. The main objective of this contribution is to characterize the activation and the functionalization of titanium surfaces by the covalent immobilization of anchoring layers of self-assembled bisphosphonate nerid...

Maria Hellgren, Fabio Caruso, Daniel R. Rohr, Xinguo Ren, Angel Rubio, Matthias Scheffler, and Patrick Rinke International School for Advanced Studies (SISSA), via Bonomea 265, 34136 Trieste, Italy Physics and Materials Science Research Unit, University of Luxembourg, 162a avenue de la Faı̈encerie, L-1511 Luxembourg, Luxembourg Department of Materials, University of Oxford, Parks Road, Oxford OX...

In dynamic force spectroscopy, single (bio-)molecular bonds are actively broken to assess their range and strength. At low loading rates, the experimentally measured statistical distributions of rupture forces can be analysed using Kramers' theory of spontaneous unbinding. The essentially deterministic unbinding events induced by the extreme forces employed to speed up full-scale molecular simu...

This paper presents a micro-biosensor based on Electrical Bio-Impedance Spectroscopy (EBIS), applied to blood cells characterization and diagnosis. This sensor uses microfluidic flow, coupled to EBIS system to perform cell by cell measurements at high flow rate, up to several hundred cells per second. Two devices were realized with different materials, SU_8 resin and polydimethylsyloxane PDMS t...

Chemical reduction of graphene oxide (GO) to graphene employs the use of toxic and environmentally harmful reducing agents, hindering mass production of graphene which is of tremendous technological importance. In this study we report a green approach to the synthesis of graphene, bio-reduced by crude polysaccharide. The polysaccharide reduces exfoliated GO to graphene at room temperature in an...

Magnetic nanoparticles have found application in medical diagnostics such as magnetic resonance imaging and therapies such as cancer treatment. In these applications, it is imperative to have a biocompatible solvent such as water at optimum pH for possible bio-ingestion. In the present work, a synthetic methodology has been developed to get a well-dispersed and homogeneous aqueous suspension of...