introduction: mesenchymal stem cells (mscs) hold great promise in the field of regenerative medicine.although originally isolated from bone marrow, mscs have since been obtained from a variety of adult and neonatal tissues including the adipose tissue. stemness and multipotential features of mesenchymal stem cells (msc) has been highlighted in many studies but there are many dark aspects in exc...

introduction: the thalassamias refer to a diverse group of hemoglobin disorders characterized by a reduced synthesis of  one or more of globin chains (α,β, γ, δβ,γδβ, δ and εγδβ).the main cure available today for thalassamia is bone marrow transplantation (bmt)  from compatible donor.on december 3, 1981 a 14-month-old child with β-thalassemia major recieved bmt from his hla-identical sister in ...

introduction: vesicovaginal fistula remains a challenge in surgical therapy. in this study autologous platelet rich plasma and platelet rich fibrin glue were used as a minimally invasive approach for vesicovaginal fistula closure. materials and methods: data including age, parity, iciq-ui (international consultation on incontinence questionnaire-urinary incontinence), iciq-qol (international co...

within a single tumor clone, cells have significantly different abilities to proliferate and form new tumors. this has led to the hypothesis that most cells in a cancer have a limited ability to divide and only a small subset of distinct cells, the cancer stem cells (cscs), has the capacity to self-renew and form new tumors . it has been proposed that the development of tumors is based exclusiv...

tissue-engineered biomaterials have existed approximately 40 years as simple biomimetic structures. replacement of human tissue with new tissue can be accomplished by generating replacements outside of the body or in situ in the body. in each case, the key elements are described as the tissue engineering triad of scaffolds, cells, and signals. scaffolds can be produced synthetically or derived ...

background  wisdom teeth are usually removed as a routine procedure for therapeutic or prophylactic reasons. developing wisdom teeth are easy accessible source of stem cells during the adulthood which could be obtained. methods  search of the pubmed for stem cells and tooth was done. an inclusion criterion was extract of stem cells from wisdom tooth. results  stem cells can be obtained from den...

background human preimplantation embryonic cells share many similarities with cancer cells such as ability to self-renew, unlimited proliferation and maintenance of the undifferentiated state. embryo-cancer sequence a (ecsa), also known as developmental pluripotency associated-2 (dppa2), is a cancer testis antigen (cta) with unclear biological function yet. objective: ctas are expressed normall...

introduction autologous plasma-rich platelet (prp) is a human platelet concentrated product which is in low volume of plasma. using prp in rejuvenation and resolution of some cosmetic problems has been already popular in many countries and also in iran. as no study performed in this field in iran and regarding the high prevalence of using prp in society with no validate references in the case o...

background adipose tissue mesenchymal stem cells (at-mscs) are suitable choices in treatment of liver associated diseases. dimethyl sulfoxide (dmso) is an amphipathic molecule with potential of delivering both lipophilic and hydrophilic agents into cells. few protocols used dmso for induction of at-mscs towards hepatocyte like cells but the effect of dmso on hepatogenic differentiation were not...

introduction there are one million deaths from asphyxia in newborn annually. management of this newborn is only supportive. autologuse stem cell therapy may reduce mortality and long term morbidity. outcome of asphyxiated newborn is related to damage cns cells. stem cells prevent apoptosis and induce repairmen of injured neurons. methods in a review study all article related to three keywords o...