hemoglobinopathies are the most common single gene disorders worldwide with a considerable frequency in certain area particularly mediterranean and middle eastern countries. hemoglobinopathies include structural variants of hemoglobin (hb s, hb c, hbe,…) and thalassaemias which are inherited defects in the globin chains synthesis. the present study was conducted to determine the prevalence of h...

A method for isolating human hemoglobin messenger RNA (mRNA) from bone marrow cells was developed to investigate the molecular basis for the defect in globin synthesis in beta thalassemia. Active mRNA was isolated from the bone marrow cells and peripheral reticulocytes of patients with homozygous beta thalassemia, heterozygous beta thalassemia, sickle cell trait, double heterozygosity for beta ...

Dear Editor, Beta Thalassemia major is a genetic disease with an autosomal recessive pattern and is differentiated by severe microcytic hypochromic hemolytic anemia with hepatosplenomegaly, ineffective erythropoiesis and bone marrow expansion. The β-globin (HBB) gene coding for β-chain expression is located on a 50 kb globin gene cluster on the short arm of chromosome 11, whose mutation mediate...

Introduction Thalassemia is a group of genetic disorders resulting in the decreased production of globin chains, alpha or beta, leading to the decreased production of hemoglobin (Hb). For the heterozygous state, it can be recognized by the microcytosis of its red blood cell or the decreased mean corpuscular volume (MCV) of less than 80 fL. For alpha-thalassemia-1 or alpha(0)thalassemia traits, ...

beta-thalassemia major (β-tm) is a chronic, genetic and hematological disorder. children and teenagers with chronic physical illnesses exemplified by thalassemia are vulnerable to emotional and behavioral problems. the aim of this study was to evaluate mental health and its related factors among young patients with beta-thalassemia major.in this cross-sectional observational descriptive-analyti...

The intracellular content of K(+) in thalassemia minor red blood cells is markedly reduced after incubation in autologous serum for 24 hr at 37 degrees C. There is no compensatory increase in intracellular Na(+) concentration of the cell thus reduced. This change is due to an acquired increase in selective permeability of the membrane to K(+). This phenomenon follows the depletion of energy sou...

abstract introduction : celiac disease (cd) is an autoimmune disorder triggered by ingestion of gluten in genetically predisposed individuals.  this study reports evaluated prevalence of cd in patients with beta-thalassemia major. materials and methods: in this case-control study in a period of 3 years  which was performed on 620 children in two groups of  beta-thalassemia major  patients (n=20...

dear editor, the problem of congenital hemoglobin disorder is common in tropical asia. in tropical southeast asian countries, very high prevalence of thalassemia disorder especially for beta thalassemia is observed. this tropical hematological problem affects millions of population and cause several health disorders. of interest, the issue of reproductive health impairment of the population wit...