background: expansion of bone marrow cavity and decreased cortical and trabecular bone tissues and osteoporosis are resulted from beta-thalassemia. the aim of this study was to assess bone mineral density (bmd) in patients with β thalassemia major and intermedia, and to determine their biochemical and hormonal profiles that may affect bmd. materials and methods: in a cross sectional study from ...

100 patients with beta-thalassemia trait, comprised of 55 men and 45 women, participated in a study to measure serum lipoproteins. the results were compared with the data obtained from 100 control subjects of the same age and sex. a significantly lower level of mean serum total cholesterol and ldl cholesterol, and a much higher level of hdl cholesterol were obtained in beta-thalassemia trait as...

Background: In various cancers, Ganoderic Acid A (GAA), an active triterpenoid derived from Ganoderma Background: Thalassemia refers to a category of inherited disorders resulting from defects in synthesizing one or several chains of hemoglobin (Hb). The present study aimed to determine the frequency of alpha and beta-thalassemia mutations in Kurdistan province, Iran. Materials and Methods: In...

BACKGROUND Delta beta (δβ) thalassemia is an unusual variant of thalassemia with elevated level of fetal hemoglobin (HbF). Homozygous patients of this disorder, unlike β-thalassemia, show mild anemia. Only few cases of δβ-thalassemia have been reported from India in the available indexed English literature. CASE PRESENTATION A four-year old male child was evaluated for recent-onset jaundice. ...

BACKGROUND: Thalassemia is the most common hereditary disease in the world. Thalassemic erythrocytes are exposed to higher oxidative stress and lipid peroxidation. The aim of this study was to investigate the effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemia patients. METHODS: A prospective double-blind, placebo-controlled study of the effect of beta-...

The phenotype of E-beta-thalassemia is affected by several genetic factors. The aim of this study was to analyze severity of E-beta-thalassemia and correlate with HbE, HbF, E/F ratios, beta-mutation and Xmn I polymorphism. Thirty cases of E-beta-thalassemia (23 with childhood onset) were studied. HbE levels were quantitated by HPLC. Xmn1 polymorphism and beta-mutations were studied by PCR-RFLP ...

background : using two logistic regression models, we determined the associates of poor physical and mental health related quality of life (hrqol) among beta thalassemia patients. methods : in this cross-sectional study which was conducted during 2006 and 2007 in outpatient adult thalassemia clinic, blood transfusion organization, tehran, iran, short form 36 (sf-36) was used for measuring hrqol...

To define how excess unpaired alpha- and beta-globin chains in severe beta-thalassemia and severe alpha-thalassemia interacting with the membrane might alter cellular and membrane properties, we performed a series of biophysical and biochemical analyses on erythrocytes obtained from affected patients. Detailed analysis of cellular and membrane deformability characteristics showed that both form...

Introduction and Objective: Zinc as the second trace element of the human body plays an important role in numerous functions. A large number of research studies have showed serum zinc deficiency and excess urinary excretion in patients with major beta thalassemia, but few studies revealed excess urinary zinc excretion in minor b...

We have developed a technique to diagnose the alpha- and beta-thalassemia (thal) syndromes using the polymerase chain reaction to amplify cDNA copies of circulating erythroid cell messenger RNA (mRNA) so as to quantitate the relative amounts of alpha-, beta-, and gamma-globin mRNA contained therein. Quantitation, performed by scintillation counting of 32P-dCTP incorporated into specific globin ...