Multiple and paradoxical effects of airway smooth muscle (ASM) 7-transmembrane-spanning receptors activated during asthma, or by treatment with bronchodilators such as beta(2)-adrenergic receptor (beta(2)AR) agonists, indicate extensive receptor crosstalk. We examined the signaling of the prostanoid-EP(1) receptor, since its endogenous agonist prostaglandin E(2) is abundant in the airway, but i...

The bovine papillomavirus E5 protein is a small, homodimeric transmembrane protein that forms a stable complex with the cellular platelet-derived growth factor (PDGF) beta receptor through transmembrane and juxtamembrane interactions, resulting in receptor activation and cell transformation. Glutamine 17 in the transmembrane domain of the 44-amino-acid E5 protein is critical for complex formati...

Regulating TGF-beta receptor presentation provides an avenue to alter a cell's responsiveness to TGF-beta. We report that activation of the Erk MAP kinase pathway decreases the TGF-beta-induced Smad3 activation due to decreased cell surface levels of the type I receptor TbetaRI, but not the type II receptor. Inhibition of TACE activity or expression enhanced the cell surface TbetaRI levels and ...

OF THE MANY beta-receptor blocking agents developed over the past two decades only one, dl-propranolol, has become generally available to American physicians. However, as experience accumulates regarding the safety and efficacy of other beta-blockers, it is likely that at least some of these drugs (many of which are widely used in Europe) will gain approval for use in the United States. Thus an...

We ligated the left anterior descending coronary artery for 1 or 2 h in 31 purebred beagles. We did not detect any changes in beta-adrenergic receptor density or affinity when normal and ischemic zones were compared, either in the subendocardium or in the subepicardium. In the ischemic zones, there was a significant decline in all measures of adenylate cyclase activity, including activity media...

OBJECTIVES: To determine the prevalence and characteristics of patients who achieved target doses angiotensin converting enzyme inhibitors (ACEIs)/ II receptor blockers (ARBs), beta-blocker, mineralocorticoid antagonists (MRAs). MATERIALS AND METHODS: A retrospective chart review study heart failure with reduced ejection fraction (HFrEF) received ACEIs/ARBs, beta-blockers, or MRAs follow-up mor...