Variable-temperature NMR experiments and ab initio density functional calculations were carried out to investigate the conformation interconversion of novel chiral 3-alkyl-3,4-dihydro-2H-benzo[1,4]oxazine derivatives. With CDCl3 as the solvent, the coalescence temperatures of H2, H3, H11, and H19 of product 1 are about 289, 304, 292, and 316 K, with the corresponding activation free energies at...

A microwave-assisted, fluorous synthetic route to 3-amino-1,2-benzisoxazoles and 4-amino-1H-2,3benzoxazines has been developed. The strategy comprises linking the respective 2-fluorobenzonitrile or 2-(bromomethyl)benzonitrile to a fluorous oxime tag to give an aryloxime intermediate which then undergoes cyclization with concomitant cleavage of the substrate-tag in acidic conditions to provide t...

BACKGROUND AND PURPOSE The 2-propyl-1,4 benzoxazine (AM10) shows a peculiar behaviour in skeletal muscle, inhibiting or opening the ATP-sensitive K(+) (KATP) channel in the absence and presence of ATP, respectively. We focused on tissue selectivity and mechanism of action of AM10 by testing its effects on pancreatic KATP channels by means of both in vitro and in vivo investigations. EXPERIMEN...

About 10,000 years ago, humans began to domesticate plants and animals. Now, it is time for us to domesticate molecules. In today’s polymer materials science, many scientists have synthesized a large number of synthetic polymers, which have been widely used in people’s lives. In a sense, natural polymers, like natural rubber, cellulose, etc., are of less importance than ever before. It is well ...

s of the 214th ACS National Meeting.20. Dong, J., S. Iuchi, H. S. Kwan, Z. Lu, and E. C. Lin. 1993. The deducedamino-acid sequence of the cloned cpxR gene suggests the protein is thecognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli. Gene 136:227–230.21. Dziejman, M., and J. J. Mekalanos. 1995. Two-component signal ...