While the equilibrium partitioning (EqP) method has been demonstrated to effectively predict adverse effects of nonionic organic chemicals in sediment on benthic organisms by toxicity tests, only a limited number studies have performed both water-only and whole-sediment tests using same species verified validity EqP-based assessment. To further examine EqP for application wide range hydrophobic...

Diverse contaminants released into the environment through progress of urbanization and industrialization adversely affect human health. Among various sources of contaminants, especially, in big cities, automobiles play a significant role in aggravating the pollution. Various pollutants viz., heavy metals (Pb, Mn, Ni, Zn, As, Hg, Cd) and Polyaromatic hydrocarbons (Benzo-apyrene, fluoranthene, p...

A highly purified and reconstituted hepatic microsomal monooxygenase system, completely free of epoxide hydrase and consisting of cytochrome P-448 from 3-methylcholanthrene-treated rats, NADPHcytochrome c reductase, phosphatidylcholine, and NADPH, metabolizes benzo [a Jpyrene to products highly mutagenic in strains TA 98 and TA 1538 of Salmonella typhimurium. The formation of mutagenic metaboli...

There are several hundred PAHs; the best known is benzo[a]pyrene -B(a)P. Most measurements have been made on B(a)P, with different sampling and analytical procedures requiring prolonged treatment of the sample and subsequent chromatographic analysis. We proposed the present method for initial screening to check for B(a)P, developing a rapid and inexpensive immunoassay method, based on antibodie...

Citation: Gomiero A, Strafella P, Pellini G, Salvalaggio V and Fabi G (2018) Comparative Effects of Ingested PVC Micro Particles With and Without Adsorbed Benzo(a)pyrene vs. Spiked Sediments on the Cellular and Sub Cellular Processes of the Benthic Organism Hediste diversicolor. Front. Mar. Sci. 5:99. doi: 10.3389/fmars.2018.00099 Comparative Effects of Ingested PVC Micro Particles With and Wit...

Treatment with either a flavone or benz(alpha)anthracene before the addition of a potent carcinogen, benzo(alpha)pyrene or 3-methylcholanthrene, enhanced the transformation of Syrian hamster cells that are seeded in order to form colonies. 7,8-benzoflavone and benz(alpha)anthracene prevented the cytotoxicity by the carcinogens, while 5,6-benzoflavone did not. The results clearly indicate that i...

Mutagenicities of 3-nitrodibenzofuran and 3-aminodibenzofuran were examined using Salmonella typhimurium TA98 and TA100. Strong mutagenicity was found in both compounds. The mutagenic potency of 3-nitrodibenzofuran was approximately 3.5-fold stronger in TA98 and twice stronger in TA100 than that of benzo[a]pyrene. Mutagenicity of 3-aminodibenzofuran was observed under metabolic activation and w...

Airborne fine particulate matter (PM2.5) pollution is known to have adverse effects on human health, and owing their carcinogenic mutagenic nature, polycyclic aromatic hydrocarbons (PAHs) are of particular concern. This study investigated the effect ultraviolet (UV)-induced photocatalysis degradation PAHs in PM2.5, employing titanium dioxide (TiO2)-supporting quartz fibre filters. A TiO2 layer ...

Covalent binding of the benzo[a]pyrene metabolite (+/-)7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene to calf thymus DNA was investigated. Enzymatic hydrolysis of the carcinogen-modified DNA and subsequent separation via reversed-phase high-pressure liquid chromatography resulted in the detection and isolation of seven distinct products. High-resolution mass spect...