In this study some novel Schiff bases derivatives of benzimidazole containing thiophene ring were designed and synthesized by using various aldehydes. Seven different aromatic aldehydes with side groups used for synthesized. 1H-NMR, 13C-NMR spectra LC-MS to identify all the compounds. All compounds anti urease activities calculated according phenol-hypochlorite method Weatherburn. The results i...

Benzimidazoles are a very well-known, broad group of compounds containing nitrogen atoms in their structure that can mimic properties DNA bases. The show not only biological activities but also used for spectral and catalytic properties. Biological activity benzimidazoles be tuned accelerated coordination compounds. This minireview is focused on preparation bis(benzimidazoles), complexes, found...

The title compound, C(24)H(26)N(4)O(4), is a diaza-crown ether encompassing linked phenylpyrazolyl and benzimidazole units that contribute five atoms to the 16-atom ring. The two planar phenylpyrazolyl and benzimidazole units are aligned at an angle of 66.4 (1)°. The carbonyl O atom of the benzimidazole unit is directed away from the middle of the ring.

In the title compound, C(30)H(26)N(4)O, the dihedral angle between the two benzimidazole rings is 69.35 (9)°. The dihedral angles between the benzimidazole ring system and the phenyl ring are 76.79 (12) and 86.10 (11)° in the two benzyl-benzimidazole moieties.

In an endeavor to find a novel series of antihyperglycemic agents, new benzimidazole and pyrimidine derivatives were successfully synthesized efficiently in high yield with high purity, starting from amino acids in the presence of phosphorus oxychloride (POCl3). The synthesized compounds were identified by 1H-NMR, 13C-NMR, FT-IR spectroscopic techniques and elemental analysis. All products were...

Presence of benzimidazole nucleus in numerous categories of therapeutic agents such as antimicrobials, antivirals, antiparasites, anticancer, anti-inflammatory, antioxidants, proton pump inhibitors, antihypertensives, anticoagulants, immunomodulators, hormone modulators, CNS stimulants as well as depressants, lipid level modulators, antidiabetics, etc. has made it an indispensable anchor for de...

Objective. To study the neuropsychotropic activity of 2,4-dioxobutanoic acid derivatives containing a fragment benzimidazole as well to determine relationship between structure substances and their biological effects.
 Materials methods. The spectrum with was studied on experimental animals using open field, black-and-white camera, extrapolation deliverance tests.
 Results. A compound...

by a single A→U point mutation3. Both the benzimidazole derivative and the mutation reduce the production of viral proteins by approximately 80%, likely by preventing formation of the complete 80S eukaryotic ribosome. Hence this small molecule does not function by competitively inhibiting the interaction between the IRES and its target. Instead, it affects IRESdriven viral protein synthesis by ...

A series of novel 2-substituted benzimidazole derivatives were synthesized and their antibacterial activity was assessed against selected Gram-positive and Gram-negative bacteria. The specific moiety at the 2-position of the benzimidazole was extensively modified with several fused heterocyclic functional groups containing nitrogen and sulfur heteroatoms. In addition, the influence of different...