Objectives: In 2018 we published the top ten list of CF research priorities, developed with James Lind Alliance (JLA). We have now undertaken a refresh 10 mandated by changes in landscape through introduction CFTR modulator drugs. Methods: an online (elicitation) survey, asked community (patients, family members, clinicians and researchers) which original priorities were still important them to...

Environmental deformations and changes put countries under socioeconomic stress at the global level are, therefore, an essential topic of discussion. In this context, paper analyzes impact financial development, tourism, economic growth on three different environmental indicators using second-generation panel data techniques for top ten tourism destinations. This study tests whether there is a ...

Over the last 40 years, starting from being nowhere, Biopharmaceutical drugs have come to occupy a dominant presence in the list of top ten selling drugs globally. Today, worldwide biopharmaceutical revenues are estimated at USD 288 billion, or 23 % of global pharmaceutical industry revenues, and comprise seven of the top ten list of drugs (Table 1). Many of these drugs, particularly monoclonal...

The degree of offshore outsourcing in the high-tech industries has increased rapidly in past decades. Because of this trend, economists have been debating whether offshore outsourcing is hollowing out U.S. high-tech firms’ core competencies in intangibles. To contribute to the debate, I first develop a forward-looking profit model and use Compustat dataset to measure the capital stock and depre...

During the last ten years, fuzzy system applications have received increasing attention in manufacturing industries, heavy industries, transportation systems, water supply systems. The applications are mainly for controllers, however, there also exist many other areas such as prediction, diagnosis, optimization, and planning. In power systems, many applications have been proposed, however, most...