Recent studies utilizing a neurotoxic model of Huntington's disease (HD) in rodents have demonstrated locomotor abnormalities following unilateral lesions of the striatum. The behavioral abnormalities are manifested as an asymmetric rotation ipsilateral to the side of the lesion following apomorphine administration. The current study provides evidence for the dependence of rotational direction ...

Tauopathies are neurodegenerative disorders characterized by the accumulation of abnormal tau protein leading to cognitive and/or motor dysfunction. To understand the relationship between tau pathology and behavioral impairments, we comprehensively assessed behavioral abnormalities in a mouse tauopathy model expressing the human P301S mutant tau protein in the early stage of disease to detect i...

The term Fetal Alcohol Syndrome [5] (FAS) was first published in a 1973 article in the British medical journal The Lancet. In that article, a group of pediatricians and psychiatrists at the University of Washington Medical School helped to define the morphological defects and developmental delays that can affect children born to alcoholic mothers. Those observations include preand post-natal gr...

We describe six individuals with microdeletions and microduplications in the distal 22q11.2 region detected by microarray. Five of the abnormalities have breakpoints in the low-copy repeats (LCR) in this region and one patient has an atypical rearrangement. Two of the six patients with abnormalities in the region between LCR22 D-E have hearing loss, which has previously been reported only once ...

Introduction: The high prevalence of adolescent cannabis use, the association between this use and later psychiatric disease, and increased access to high-potency cannabis highlight the need for a better understanding of the long-term effects of adolescent cannabis use on cognitive and behavioral outcomes. Furthermore, increasing Δ9-tetrahydrocannabinol (THC) in high-potency cannabis is accompa...

background:   objective: the objective of the present study was to evaluate the application of two dimensional ultrasound (2-dus) and real time three dimensional ultrasound (3-dus) in differentiating various type of septated uterus. hysteroscopy confirmation was assigned as the gold standard.   materials and methods: this retrospective study was performed among 215 infertile women with suspecte...

Childhood epilepsy is a chronic, recurrent disorder of unprovoked seizures. The onset of epilepsy in childhood has significant implications for brain growth and development. Seizures may impair the ongoing neurodevelopmental processes and compromise the child’s intellectual and cognitive functioning, leading to tremendous cognitive, behavioral and psychosocial consequences. Children with epilep...

BACKGROUND Interictal behavioral symptoms in frontal lobe epilepsy (FLE) are variable and often difficult to discriminate from other localization-related epilepsies. METHODS AND RESULTS We report two female patients with right FLE who exhibited fantastic confabulations. One of the patients had a 14-year history of hypermotor seizures, and the other had a 10-year history of dyscognitive seizur...

Behavioral phenotyping of transgenic and knockout mice requires rigorous, formal analyses. Well-characterized paradigms can be chosen from the established behavioral neuroscience literature. This review describes (1) a series of neurological and neuropsychological tests which are effectively used as a first screen for behavioral abnormalities in mutant mice, and (2) a series of specific behavio...

Abstract Background The loss of dopamine neurons in the substantia nigra, as well other mostly catecholaminergic neurons, causes many motor symptoms that define Parkinson's disease. disease is commonly thought a movement disorder, significant prevalence psychiatric complications such cognitive impairment, and psychosis suggests it should be considered neuropsychiatric illness, all behavioral ar...