The emergence of drug-resistant tuberculosis (TB) is a growing problem worldwide. The lack of safe and effective drugs, together with the frequent development of adverse drug reactions can result in worse outcomes. Therefore, new TB drugs able to bolster the current TB treatment regimen are urgently required. Novel drugs that are effective and safe against Mycobacterium tuberculosis are require...

Despite overall progress in global TB control, the rising burden of multidrug-resistant TB (MDR-TB) threatens to undermine efforts to end the worldwide epidemic. Of the 27 countries classified as high burden for MDR-TB, 17 are in 'low' or 'low-middle' income countries. Shorter, all oral and less toxic multidrug combinations are required to improve treatment outcomes in these settings. Suitabili...

For the past three years Bahia has the opportunity to sponsor the Tuberculosis Research Meeting in Bahia. These meetings are responses to the need of increasing the quantity and quality of research in tuberculosis. In this last meeting Dr. Christian Lienhardt from the WHO tuberculosis program presented impressive and convincing figures of the impossibility of eliminating tuberculosis without a ...

Affiliations: Médecins Sans Frontières, Paris, France. APHP, Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux, Bactériologie-Hygiène, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Paris, France. Sorbonne Université, UPMC Université Paris 06, CR7, INSERM, U1135, Centre d’Immunologie et des Maladies Infectieuses, CIMI, Team E13 (Ba...

The recent accelerated approval for use in extensively drug-resistant and multidrug-resistant-tuberculosis (MDR-TB) of two first-in-class TB drugs, bedaquiline and delamanid, has reinvigorated the TB drug discovery and development field. However, although several promising clinical development programs are ongoing to evaluate new TB drugs and regimens, the number of novel series represented is ...

The emergence and spread of multidrug-resistant extensively drug-resistant (MDR/XDR) Mycobacterium tuberculosis strains require new antituberculosis compounds. Bedaquiline is a novel promising drug, but as with other drugs, bedaquiline resistance can be acquired by M. during long-term treatment. In particular, atpE mutations prevent interaction the drug its target, ATP synthase in efflux pump r...