This paper introduces a novel technique for sequential blind extraction of singularly mixed sources. First, a neural-network model and an adaptive algorithm for single-source blind extraction are introduced. Next, extractability analysis is presented for singular mixing matrix, and two sets of necessary and sufficient extractability conditions are derived. The adaptive algorithm and neural-netw...

Binding of antigen to B-cell antigen receptor (BCR) leads to antigen internalization and presentation to T cells, a critical process in the initiation of the humoral immune response. However, antigen internalization has been demonstrated for soluble antigen, in vivo antigen is often encountered in insoluble form or tethered to a cell surface. Here, we show that not only can B cells internalize ...

A simple and rapid ultrasound assisted extraction (UAE) protocol with dilute solutions of tetramethylammonium hydroxide (TMAH) for the speciation of mercury in fish and plant tissues was developed as an alternative to conventional methods which require intensive treatments. The main operational parameters, such as extractant concentration (TMAH), sonication time and amount of sample, were optim...

The aim of this study was to determine the extent of metal pollutions and the identification of their major sources in the vicinity of the Sangan iron mine occurring in NE Iran. Soil samples were collected from the vicinity of the mine site and analyzed for heavy metals. In addition, the chemical speciation of these metals was investigated by means of the sequential extraction procedure. The st...

Background: RNA interference (RNAi) is the mechanism of gene silencing-mediated messenger RNA degradation by small interference RNA (siRNA), which becomes a powerful tool for in vivo research, especially in the areas of cancer. In this research, the potential use of an expression vector as a specific siRNA producing tool for silencing of Bcr-abl in K562 cell line has been investigated. Methods:...

PURPOSE Dasatinib and nilotinib are active in imatinib-resistant chronic myelocytic leukemia (CML) and many patients undergo sequential treatment. We aimed at modeling sequential tyrosine kinase inhibitor (TKI) resistance in vitro to compare the sequences imatinib-nilotinib-dasatinib and imatinib-dasatinib-nilotinib. EXPERIMENTAL DESIGN We designed an in vitro model for sequential TKI resista...