Myelomonocytic cells play a key role in the progression of many solid tumors. However, very little is known about their contribution to the progression of hematopoietic cancers. We investigated the role of monocytes in the progression of human B-cell precursor acute lymphoblastic leukemia (BCP-ALL). We demonstrated that coculturing human monocytes in vitro with CD19 BCP-ALL blasts from patients...

This paper proposes a methodological approach that supports Collective Intelligence towards the design and development of a Business Continuity Plan (BCP), in order to minimize the potential of a disaster in the organization. In this framework, Collective Intelligence (CI) is supported by Web2.0 technologies that act as a diagnostic tool, providing the ability to the community of an organizatio...

Several studies have shown that macro micro porous bioceramics ectopically implanted promote bone tissue formation. This study aims at investigating the inflammatory response towards biphasic calcium phosphate (BCP) ceramic micro particles. BCP composed of hydroxyapatite (HA) and beta-tricalcium phosphate, HA/beta -TCP ratio of 50/50, were prepared by sintering at 1200 degrees C for 5 h. After ...

The aim of this study was to evaluate the synergistic effect of platelet-rich plasma (PRP) and recombinant human bone morphogenic protein (BMP)-2 on accelerated osteogenesis of hydroxyapatite/β-tricalcium phosphate mixture and biphasic calcium phosphate (BCP) in mastoid obliteration. To the best of our knowledge, there have been no studies reporting the enhancing effects of BCP, combined with B...

This study was aimed to produce a clinically applicable model of composite bone graft capable of treating CSBDs in the mandible with a single surgical procedure. Twelve male white New Zealand rabbits were divided into two groups: control, n=4, consisting of A (untreated) and B (BCP/FS); experimental, n=8, named C (BCP/FS) and D (BCP/FS+VEGF). A circular CSBD (8-mm Ø) was created on both sides o...

Bone substitutes alone or supplemented with platelet-derived concentrates are widely used to promote bone regeneration but their potency remains controversial. The aim of this study was, therefore, to compare the regenerative potential of preparations containing autologous platelet lysate (APL) and particles of either deproteinized bovine bone mineral (DBBM) or biphasic calcium phosphate (BCP),...

Parkinson's disease (PD) is one of the most common neurodegenerative disorders and is characterized by the loss of dopaminergic neurons in the substantia nigra (SN). Although the causes of PD are not understood, evidence suggests that its pathogenesis is associated with oxidative stress and inflammation. Recent studies have suggested a protective role of the cannabinoid signalling system in PD....

The widespread plant volatile beta-caryophyllene (BCP) was recently identified as a natural selective agonist of the peripherally expressed cannabinoid receptor 2 (CB₂). It is found in relatively high concentrations in many spices and food plants. A number of studies have shown that CB₂ is critically involved in the modulation of inflammatory and neuropathic pain responses. In this study, we ha...

The cadherin gene FAT1, located on chromosome 4q34-35 (ref. 1) within a region frequently deleted in human cancers, encodes a large protein with 34 extracellular cadherin repeats. In solid tumors, aberrant expression of FAT1 was found to be associated with disease progression. Although the gene was originally cloned from a human T-cell acute lymphoblastic leukemia (T-ALL) cell line, FAT1 just r...

This paper proposes new algorithms for the Binate Covering Problem (BCP), a well-known restriction of Boolean Optimization. Binate Covering finds application in many areas of Computer Science and Engineering. In Artificial Intelligence, BCP can be used for computing minimum-size prime implicants of Boolean functions, of interest in Automated Reasoning and Non-Monotonic Reasoning. Moreover, Bina...