نتایج جستجو برای: bax bcl 2 ratio
تعداد نتایج: 2885727 فیلتر نتایج به سال:
To explore the potential mechanism of nobiletin in improving sensitivity breast cancer MDA-MB-231 cells to Pirarubicin. were randomly divided into Control group, Nobiletin Pirarubicin group and co-Pirarubicin group. CCK-8 assay was used detect inhibitory effect on proliferation cells, cell cycle apoptosis detected by flow cytometry. The combined with migration repair ability scratch test. Weste...
Background and Objectives: Giant cell Tumor of bone (GCT) is often regarded as a benign tumor, but its clinical course is unpredictable, has a high rate of recurrence, and even can metastases and transform to a malignant tumor. Histological features of the tumor often could not predict its future biologic behavior, so it is just called ''Giant cell tumor'' without indicating maligna...
The close relationship between free radicals effects and apoptosis process has been proved. Melatonin has been reported as a direct free radical scavenger. We investigated the capability of melatonin in the modification of radiation-induced apoptosis and apoptosis-associated upstream regulators expression in rat peripheral blood lymphocytes. Rats were irradiated with a single whole body Cobalt ...
urokinase plasminogen activator receptor (upar) and its ligands play a major role in many tumors by mediating extracellular matrix degradation and signaling cascades leading to tumor growth, invasion and metastasis. recently we introduced upar decapeptide antagonist with cytotoxic effect on mda-mb-231 cell line. in this study we assessed the alteration in upar downstream signaling following tre...
To investigate the mechanism of inhibition of breast cancer cell proliferation by a newly developed photosensitizer chrolophyll derivative CPD4. MCF-7 cells were treated with CPD4 in different concentrations for 2 h, followed by irradiation (670 nm, 10 J/cm(2)) using a semiconductor laser. Apoptotic mode and ratio of treated cells were analyzed. Subcellular localization of CPD4 were observed. M...
Mediterranean spotted fever (MSF) is widely prevalent in many endemic regions in Bulgaria. The disease is still not quite thoroughly studied as to some aspects of its pathogenesis and especially to issues that concern the crucial signals for apoptosis in the target microvascular endothelial cells. To study the expression of Bcl-2 family proteins and Caspase-3 in the dermal capillary endothelial...
BACKGROUND In this study, the putative interactions between apoptosis and heat shock proteins disturbed as a result of ATP depletion were investigated as a hypoxia model. METHODS The direct cellular damages were assessed by the release of LDH from the cytoplasm of the human tubular epithelial cells (HK-2 cells) following ATP depletion. The Bcl-2/Bax mRNA expression ratio, used as an index to ...
Background: Although some studies have studied the mechanism of action of beta cells in animal models and more or less in human populations, but so far the role of exercise therapy or exercise exercise HIIT with black grape supplementation on the expression of genes involved in pancreatic beta cells This study investigates the effect of black grape supplementation combined with intense intermit...
چکیده مقدمه : امروزه استفاده از انجماد شیشه ای برای نگه داری طولانی مدت جنین ها امری روتین می باشد. همچنین در برخی از موارد جنین های گرم شده را به دلایلی مانند آماده نبودن اندومتر مجددا منجمد می کنند. لذا مطالعه در مورد میزان تکوین جنین ها و تغییر بیان ژن پس از انجماد شیشه ای مجدد ضروری به نظر می رسد. هدف از این مطالعه بررسی تاثیر انجماد شیشه ای مجدد بر میزان تکوین و بیان ژن هایbax، bcl-2 و ...
Background: Interval exercises are a way to improve exercise performance. Oxidative stress caused by interval exercises and stress on the immune system is possible induced apoptosis change in indicators Bax and Bcl-2. Resveratrol may be effective in reducing apoptosis induced by interval exercises. The present study investigates the simultaneous use of resveratrol and interval exercises on apop...
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