Medicinal mushrooms have profound health-promoting benefits. Recently, a number of substances of mushroom origin have been isolated, identified and shown to have physiological activities, such as antitumor, immunomodulating, cardiovascular, antihypercholesterolemia, antibacterial, antiviral, antiparasitic, hepatoprotective, and antidiabetic activities. Currently, commercial products from medici...

Production of different pectinolytic enzymes was attempted using the actinomycete strain Streptomyces lydicus in submerged fermentation. Polygalacturonase and pectin lyase activities were detected in the culture supernatant, but the strain was not able to produce pectin esterase. Polygalacturonase production was studied in submerged, slurry-state and solid-state fermentation systems. All the ex...

The xylanase production by a new Cochliobolus sativus Cs5 strain was improved under submerged fermentation. The xylanase was induced by xylan and repressed by glucose, sucrose, maltose, xylose, starch and cellulose. Highest enzyme production (98.25 IU/mL) was recorded when wheat straw (4 % by mass per volume) was used as a carbon source after 120 h of incubation. NaNO3 increased xylanase produc...

On-line monitoring of insect cell cultures used for the production of recombinant proteins with the baculovirus expression vector system (BEVS) provides valuable tools for the optimization, operation, and control of the production process. The relative permittivity (epsilon') and CO(2) evolution rates (CER) were measured on-line using the biomass monitor and the infrared CO(2) analyzer, respect...

Fungal cultures were isolated from soil samples collected from the Western Ghats regions of Kerala. Primary screening of isolated strains were done by Sudan black staining method and 15 lipid producing cultures were isolated. The fatty acid profiling of the positive strains were analyzed for docosahexaenoic acid (DHA) production. Selected oleaginous cultures were grown in submerged culture cond...

Suspension cultures of Taxus canadensis were elicited with methyl jasmonate (MJ) under defined headspace ethylene concentrations. Kinetic studies of growth, nutrient consumption, pH variation, and paclitaxel accumulation were conducted in batch cultures and semicontinuous culture with total cell recycle. A dramatic increase of paclitaxel was obtained when the cultures were elicited with 100 mic...

As the biopharmaceutical industry evolves to include more diverse protein formats and processes, more robust control of Critical Quality Attributes (CQAs) is needed to maintain processing flexibility without compromising quality. Active control of CQAs has been demonstrated using model predictive control techniques, which allow development of processes which are robust against disturbances asso...

Submerged Cells The formation of a liquid meniscus in submerged cell cultures is common, but its impact on vitro particle dosimetry has been overlooked. In article number 2206903, through experiments and mathematical modeling, Sandor Balog, Alke Petri-Fink, co-workers identify key factors influencing nanoparticle dose observe significant gradient between the center wall culture plates.

Various chemical compounds, including surfactants, when introduced to culture media may increase the permeability of cellular membranes and thereby affect the quantity of metabolites excreted by cells. The aim of the present study was to evaluate the impact of detergents including Triton X-100, Span 20 and Tween 80 on erythritol production from glycerol by Yarrowia lipolytica Wratislavia K1 in ...

Biodesulfurization of coal has been carried out in batch culture of single strain and mixed culture of sulfur oxidizing bacteria. The pure cultures of Thiobacillus thiooxidans and Thiobacillus ferrooxidans utilized inorganic sulfur content of Malaysian coal. The chemolithotroph bacteria were able to grow on coal and metabolize the coal's sulfur content. The batch cultures of coal with 3-5 perce...