conversion of knee arthrodesis to total knee arthroplasty is a difficult procedure accompanied by many complications due to soft tissue and extensor mechanism contracture and bone defects. we report two cases of distal femur osteosarcoma that had been undergone wide resection arthrodesis initially. arthrodesis was converted to total knee arthroplasty with hinged prosthesis after many years. we ...

mucopolysaccharidoses are a group of rare mostly autosomal recessive metabolic and genetic disorders. because of the high rate of consanguinity, they are not uncommon in our population. clinical diagnosis is not difficult for experienced physicians, but it is not enough for treatment and prevention measures in the future pregnancies. so, it is necessary to detect the type of mps by measurement ...

The aim of this study was to investigate the clinical outcome of removable partial dentures (RPDs) designed to minimize denture mobility during function. Using archived files of the undergraduate program between 2003 and 2005 at Tokyo Medical and Dental University, a list of 169 patients treated with 184 RPDs was created. The RPDs had either an acrylic resin-base or a cobalt-chrome framework-ba...

Deamination of 5-methylcytosine residues in DNA gives rise to the G/T mismatched base pair. In humans this lesion is repaired by a mismatch-specific thymine DNA glycosylase (TDG or G/T glycosylase), which catalyzes specific excision of the thymine base through N-glycosidic bond hydrolysis. Unlike other DNA glycosylases, TDG recognizes an aberrant pairing of two normal bases rather than a damage...

Extensibility is one of many claims of improved performance being made for distributed processing systems. Extensibility means system properties, such as "incremental growth and configuration flexibility," "highly adaptable to changes in workload," "incremental replacement and/or upgrading of components (both hardware and software)" and "easily expanded in both capacity and function."2 Although...

We have used NMR spectroscopy to characterize an oligonucleotide stem loop structure based on the pre-element of an oncogenic microRNA, miR-21. This predicted stem-loop structure is cleaved from the precursor of miR-21 (pre-miR-21) by the nuclease Dicer. It is also a critical feature recognized by the protein complex that converts the primary transcript (pri-miR-21) into the pre-miRNA. The seco...

BACKGROUND This study aims to investigate the effects of a modified, balanced crystalloid including phosphate in a perioperative setting in order to maintain a stable electrolyte and acid-base homeostasis in the patient. METHODS/DESIGN This is a single-centre, open-label, randomized controlled trial involving two parallel groups of female patients comparing a perioperative infusion regime wit...

BACKGROUND The obective of this study was to perform a cost-effectiveness analysis comparing intermittent with continuous renal replacement therapy (IRRT versus CRRT) as initial therapy for acute kidney injury (AKI) in the intensive care unit (ICU). METHODS Assuming some patients would potentially be eligible for either modality, we modeled life year gained, the quality-adjusted life years (Q...

OBJECTIVES To investigate in a prospective follow up the longevity of posterior resin composites (RC) placed in permanent teeth of children and adolescents attending Public Dental Health Service. METHODS All posterior RC placed, in the PDHS clinics in the cities of Copenhagen and Frederiksberg in Denmark between November 1998 and December 2002, in permanent teeth of children and adolescents u...