Allelic imbalance (AI) encompassing the apoptotic protease-activating factor 1 (APAF-1) locus (12q22-23) is found frequently in metastatic melanoma. Circulating DNA with AI on 12q22-23 in serum was evaluated as a surrogate marker to predict biochemotherapy (BC) treatment response in melanoma patients. Sera were collected from 49 American Joint Committee on Cancer stage IV melanoma patients trea...

PURPOSE Our objective was to determine the risk factors for inpatient admission of pediatric burn patients. MATERIALS & METHODS This cross-sectional study uses data from the Healthcare Cost and Utilization Project Kids' Inpatient Database (HCUP KID) for the years of 2003, 2006, 2009, and 2012 to estimate the risk factors for inpatient admission for pediatric patients who sustained a burn inju...

The mesostriatal dopaminergic system, which comprises the mesolimbic and the nigrostriatal pathways, plays a major role in neural processing underlying motor and limbic functions. Multiple reports suggest that these processes are influenced by hemispheric differences in striatal dopamine (DA) levels, DA turnover and its receptor activity. Here, we review studies which measured the concentration...

1Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China 2Department of Neurology, Xijing Hospital, The Fourth Military Medicine University, Xi’an 710032, China 3School of Dentistry, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Heath Park, Cardiff CF14 4XY, UK 4Department of Neurology, Henry Ford Hospital, Detroit, MI 482...

In this paper we give a systematic analysis of the relationship between imbalance and overlap as factors influencing classifier performance. We demonstrate that these two factors have interdependent effects and that we cannot form a full understanding of their effects by considering them only in isolation. Although the imbalance problem can be considered a symptom of the small disjuncts problem...

This paper will review literature on Western mediation to determine whether power balance is an issue that is considered in the theoretical literature on this subject. The impact of power imbalance on the mediation process will be discussed. Attention will also be given to the role of mediators and participants in wielding influence over the power dynamic in mediation. The premise that there ar...

Climate change from increased greenhouse gases arises from a global energy imbalance at the top of the atmosphere (TOA). TOA measurements of radiation from space can track changes over time but lack absolute accuracy. An inventory of energy storage changes shows that over 90% of the imbalance is manifested as a rise in ocean heat content (OHC). Data from the Ocean Reanalysis System, version 4 (...

Background: Acid-base and electrolytes disorders are commonly seen in critically ill patients. Electrolyte abnormalities were the most frequent extra cranial occurrence of altered consciousness. There are multiple studies which reported altered survival outcome in low GCS patient and some did not. Aims: To assess the survival outcome of acid-base electrolyte imbalance associated with low GCS pa...

Tc-99m dimercaptosuccinic acid (DMSA) is used as a renal cortical imaging agent to detect parenchymal abnormalities especially in children. Kidney uptake of DMSA provides an index for evaluation of a functional tubular mass, which depends on the renal blood flow and proximal tubular cell membrane transport function. We here report a boy with renal tubular acidosis, which has noticeably reduced ...

Hyponatremia is a common and potentially serious complication of transsphenoidal surgery (TSS). Since September 2009, we have implemented moderate water intake restriction (< 2500 mL/day) after TSS in an attempt to prevent this complication. The aim of this study was to investigate the efficacy of a combination of moderate restriction of water intake plus antidiuretic hormone (arginine vasopres...