Basal cell carcinoma (BCC) is currently the most common cutaneous cancer found in humans. Although it generally shows a relatively benign course (BCCl), some cases show aggressive behavior (BCC2). Until recently, traditional histologic diagnostic criteria have failed to discriminate unequivocally between BCC 1 and BCC2. In this study we selected 50 cases of BCC and categorized them into tw...

Background & Objective:Basal cell carcinoma (BCC) is classified into BCC1 or low risk (nodular, superficial type) and BCC2 or high risk (micronodular, morpheaform, infiltrative, and basosquamous types) based on clinical behavior. This study attempts to evaluate immunohistochemical (IHC) findings and clinical features associated with local aggressiveness and recurrence ...

Intrahepatic clear cell bile duct adenoma is extremely rare, with only 3 previous cases reported in the literature. The cause of cytoplasmic clearing in clear cell bile duct adenoma has not been previously investigated. Distinguishing clear cell bile duct adenoma from other clear cell tumors, particularly clear cell cholangiocarcinoma, can be challenging. Previous studies have shown loss of CD1...

OBJECTIVE To report 2 cases of coexisting mucous retention cyst and basal cell adenoma arising from the lining epithelium of the cyst. CLINICAL PRESENTATION AND INTERVENTION Two cases of painless swellings, well-demarcated, soft to palpation, and located in the submucosa of the upper lip were clinically examined with the provisional diagnosis of mucocele or salivary gland tumor. Histological ...

introduction the application of immunohistochemical method has resulted in marked improvement of the microscopic diagnosis of neoplasms combined with h&e; staining. although unique cellular antigens have not been found in salivary gland neoplasms, multiple less specific immunomarkers have been used and may be helpful in elucidating the role of myoepithelial differentiation in those neoplasms. t...

this case report describes a 59-year-old woman with a giant basal cell carcinoma on the face neglected for 11 years. surgical resection of the lesion resulted in a 13 × 11 cm defect. issues regarding the adequately safe surgical margins and the management of the resultant defect through modern wound dressing technologies are discussed. keywords : giant basal cell carcinoma, modern dressing, gel...

Previous studies have shown that CCNB1 affects the invasiveness of pituitary adenomas, and it is great significance to find upstream mechanism regulating CCNB1.In this study, we explored a significantly overexpressed circRNA in invasive adenomas. Based on bioinformatics analysis experiments, determined circNFIX (has-circ_0005660) cell invasion, migration proliferation adenomas by sponging miR-3...

BACKGROUND Pituitary adenoma is a common intracranial tumor in neurosurgery. Some pituitary adenomas have the characteristics of invasive growth make them unable to be removed completely by surgery leading to easy relapse. Discoidin domain receptor l (DDR1) is a new kind of tyrosine kinase receptor on the cell surface. DDR1 can be activated by tumor microenvironment signal in tumorigenesis, inc...

Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...