Lentiviral vectors are among the promising viral based-vectors in gene therapy applications, but the efficiency of their targeting needs to be improved. (Strept)avidin-biotin adaptor system is a novel approach to modify the lentiviral envelope for better targeting properties. Herein, we describe utilization of this adaptor system by designing a candidate envelope protein-bearing biotin acceptor...

OBJECTIVES Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH). However, it is still not clearly explained how the electron transfer is mediated by NADPH:CYP oxidoreductase (POR), another component of the microsoma...

The adsorption of benzo(a)pyrene (BaP) on to three types of asbestos (chrysotile antophyllite, and amosite) and three types of manmade mineral fibres (MMMF) (rock wool, slag wool, and glass wool) in a physiological water solution was studied. Adsorption was determined from the decrease in the liquid concentration of BaP on the addition of the solid material. Results show that all the fibres wea...

This is the first study to demonstrate that benzo(a)-pyrene (BaP) was able to enhance the production of parathyroid hormone‑related protein (PTHrP) by human non‑small cell lung cancer H460 cells. Such effect would further contribute to bone metastasis of lung cancer by increasing osteoclastogenesis. This study is also the first to reveal that tricetin (TCN), a flavonoid derivative found in Myrt...

MPEG-4 Body Animation Parameters (BAPs) are used for animation of MPEG-4 compliant virtual human-like characters. Distributed virtual reality applications and networked games on mobile computers require access to locally stored or streamed compressed BAP data. Existing MPEG-4 BAP compression techniques are inefficient for streaming, or storing, BAP data on mobile computers, because (a) MPEG-4 c...

BACKGROUND The Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial showed that survival in patients with severe lower limb ischemia (rest pain, tissue loss) who survived postintervention for >2 years after initial randomization to bypass surgery (BSX) vs balloon angioplasty (BAP) was associated with an improvement in subsequent amputation-free and overall survival of about 6 ...

Introduction This initial cost-effectiveness evaluation compared the provision of transtibial bone-anchored prostheses (TTA-BAPs) with socket-suspended (TTA-SSPs) over a 6-year time horizon from governmental prosthetic care perspective. The purposes were to present ways we dealt barriers encountered during analysis. objectives detail extraction baseline and incremental costs utilities required ...

(1) Objective: Highlight the in vitro effects of 3T3-L1 cell exposure to polychlorinated biphenyls (PCB118 and 153) or benzo(a)pyrene (BaP) alone or as a cocktail on adipogenesis (ADG) by focusing on changes in lipid metabolism and inflammatory-related genes expression (INFG) and ADG-related genes expression (ADGG); (2) Results: Treatment from the early stage of cell differentiation by BaP alon...

Article info: Received: 9 April 2014 Accepted: 6 August 2014 ABSTRACT An effective in vitro culture system for mature nodal segments of European plum (Prunus domestica) was established. Several important aspects of regeneration from nodal explants were studied for adaptation of European plum in Bangladesh. Leaf explants were used for callus induction and 1⁄2 MS media supplemented with 1.0 mg/l ...

This study was conducted to observe the effects of exogenous gibberellic acid3 (GA3) and 6-benzylaminopurine (BAP) treatments on growth inflorescence initiation Phalaenopsis determine whether hormonal applications can substitute for low-temperature exposure floral transition. Queen Beer ‘Mantefon’ clones were treated with no hormones (control), GA3 100 mg/L, 200 BAP mg/L + by foliar spray. The ...