Within the mammalian ovary, oocytes remain arrested at G2 for several years. Then a peri-ovulatory hormonal cue triggers meiotic resumption by releasing an inhibitory phosphorylation on the kinase Cdk1. G2 arrest, however, also requires control in the concentrations of the Cdk1-binding partner cyclin B1, a process achieved by anaphase-promoting complex (APC(Cdh1)) activity, which ubiquitylates ...

Lenstra, Lenstra, and Lovász in [7] proved several inequalities showing that the vectors in an LLL-reduced basis are short, and near orthogonal. Here we present generalizations, from which with k = 1, and k = n we can recover their inequalities: Theorem 1. Let b1, . . . , bn ∈ R be an LLL-reduced basis of the lattice L, and d1, . . . , dk arbitrary linearly independent vectors in L. Then ‖b1 ‖ ...

Let G be a graph, u be a vertex of G, and B(u)(or BG(u)) be the set of u with all its neighbors in G. A sequence (B1, B2, ..., Bn) of subsets of an n-set S is a neighborhood sequence if there exists a graph G with a vertex set S and a permutation (v1, v2, ..., vn) of S such that B(vi) = Bi for i = 1, 2, ..., n. Define Aut(B1, B2, ..., Bn) as the set {f : f is a permutation of V (G) and (f(B1), ...

Cyclin B1, a key component in the control of cell cycle progression from G(2) to M phase, has been implicated in tumorigenesis and the development of malignancy. However, the underlying mechanism by which cyclin B1 acts as an important oncogenic molecule remains largely unknown. Here we show that ectopic expression of cyclin B1 promotes cell proliferation, enhances cell motility and migration a...

Four oilseeds providing cocoa-butter substitutes--shea, pentadecima, illipe, and salseed--when tested as substrates for aflatoxin production by two strains of Aspergillus parasiticus, gave varying levels of aflatoxin. Aflatoxins were found at low levels occurring naturally in moldy shea-nuts, but none of 21 commercial shea-nut samples contained greater than 20 micrograms of aflatoxin B1 per kg.

GARP/LRRC32 was defined as a marker of activated human regulatory T cells (Tregs) that is responsible for surface localization of latent TGF-b1. We find that GARP and latent TGF-b1 are also found on mouse Tregs activated via TCR stimulation; however, in contrast to human Tregs, GARP is also expressed at a low level on resting Tregs. The expression of GARP can be upregulated on mouse Tregs by IL...

A strategy for the detection of aflatoxin B1 using a capacitive biosensor has been studied. The use of proteins for the generation of sites with high specificity against aflatoxin B1 are produced via bioimprinting. This technique has become a tool for the detection of aflatoxin B1 using a capacitive biosensor. The results demonstrate the ability to generate specific interactions with aflatoxin ...

(75) Inventors: Matthew Ralph Maschmann, Chandler, AZ (US); Timothy Scott Fisher, West Lafayette, IN (US); Timothy Sands, West Lafayette, IN (US); Rashid Bashir, West Lafayette, IN (US) 5,382,417 A 5,993,694 A 6,129,901 A 6,139,713 A 6,217,828 B1 6,232,706 B1 6,297,592 B1 6,359,288 B1 6,465,132 B1 1/1995Haase 11/1999 Ito et al. 10/2000 Moskovits et al. ........ 423/447.3 10/2000 Masuda et al. 4...

BACKGROUND To better understand the relationship between mitotic delay and the disruption of cyclin B1 and p21 in x-irradiated fibroblasts, studies were carried out to establish correlations between the downregulation of cyclin B1 by the cyclin kinase inhibitor (CKI) p21 and the induction of mitotic delay in the NIH3T3 fibroblast. MATERIALS AND METHODS Cell cycle kinetics were used to analyze...