BACKGROUND Depression is common and the efficacy of antidepressants is suboptimal. High plasma homocysteine has been consistently associated with depression, and treatment with certain B vitamins demonstrably reduces its concentration. AIMS To determine whether vitamins B6, B12 and folic acid enhance response to antidepressant treatment over 52 weeks. METHOD Randomised, double-blind, placeb...

B vitamins are some of the most commonly required biochemical cofactors in living systems. Therefore, cellular metabolism of marine vitamin-requiring (auxotrophic) phytoplankton and bacteria would likely be significantly compromised if B vitamins (thiamin B(1), riboflavin B(2), pyridoxine B(6), biotin B(7), and cobalamin B(12)) were unavailable. However, the factors controlling the synthesis, a...

1. The B-vitamins in milk from baboons (Papio cynocephalus) at various stages of lactation were measured microbiologically. 2. Mature milk contained, on average (microgram/ml): thiamin 0.18 riboflavin 0.74, nicotinic acid 3.2, folate 0.03, vitamin B6 0.70 vitamin B12 0.002, pantothenic acid 2.63, biotin 0.0065. 3. Colostrum contained much less vitamin B6 and pantothenic acid than mature milk; o...

OBJECTIVE To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C>T and 1298 A>C). MATERIAL AND METHODS We conducted a nested case-control study within a perinatal cohort of women recruited in the state of Morelos, Mexico. Twenty-three women with S...

A competitive CZE method for quality control analysis of multivitamin preparations and veterinary products containing B-group vitamins was developed. Vitamins of interest are thiamine hydrochloride (B(1)), thiamine monophosphate chloride (B(1a)), riboflavine (B(2)), riboflavine-5'monophosphate (B(2a)), nicotinamide (B(3)), d-pantothenic acid calcium salt (B(5)), pyridoxine hydrochloride (B(6)),...

BACKGROUND Malnutrition is a widespread problem in elderly people and is associated with cognitive decline. However, interventional studies have produced ambiguous results. For this reason, we wanted to determine the effect of micronutrient supplementation on blood and tissue levels and on general nutritional status in persons with mild or moderate cognitive impairment. METHODS We performed a...

Background: Human milk is the subject of many studies, but procedures for representative sample collection have not been established. Our improved methods for milk micronutrient analysis now enable systematic study of factors that affect its concentrations.Objective: We evaluated the effects of sample collection protocols, variations in circadian rhythms, subject variability, and acute maternal...

BACKGROUND Micronutrient status may be a contributing factor to the development of childhood obesity in many industrializing countries passing the nutritional transition. The few studies investigating associations between serum concentrations of vitamin B and intake of B vitamins with adiposity, however, have reported inconsistent findings. OBJECTIVE The aim of the study was to examine associ...

Serum total homocysteine (tHcy) has been implicated in promoting venous thromboembolic events and atherosclerosis, manifested as coronary heart disease, stroke or peripheral arterial disease. Dietary supplementation with B vitamins that lower tHcy concentrations was expected to reduce cardiovascular disease (CVD) risk. However, recent metaanalyses of prospective observational studies and random...