An epidemic of viral hepatitis was studied in the Okitsu area of Shimizu city in Japan from April 1980 to November 1981. One hundred thirty-six serum samples from patients with viral hepatitis were tested for hepatitis B virus, hepatitis A virus, Epstein-Barr virus, and cytomegalovirus infection. Immunoserological data showed the outbreak of viral hepatitis to be non-A, non-B hepatitis. Epidemi...

background hepatocellular carcinoma (hcc), a major fatal cancer worldwide, is induced by different etiological factors in the liver. objectives to gain insight into serum protein profiling of hcc with different etiologies. patients and methods we subjected the sera of hbv-hcc, hcv-hcc, non-b non-c-hcc patients, and healthy volunteers to two-dimensional gel electrophoresis (2-de) and liquid chro...

Despite over a decade of intensive investigation, non-A, non-B hepatitis (NANBH) remains an etiologic, diagnostic, and therapeutic dilemma. At issue are the nature of the causative agent, the clinical significance of the disease and the methods for detection, interven­ tion and prevention. This brief review will focus on only selected aspects of this dilemma and concentrate primarily on the kno...

tions and hospital admissions (r=09; p<0 01). There was a tendency throughout the period, when the figures for whooping cough increased, for the number of notifications to increase proportionately more than the number of admissions. In the peak quarters of 1974 and 1978 there were 25 and 58 admissions and 159 and 666 notifications respectively. We studied Hospital Activity Analysis statistics f...

Virus-like particles (VLPs) with a mean diameter of 32 nm were recovered from the stools of three acute phase cases of enterically transmitted non-A, non-B hepatitis (ET-NANBH) occurring in the Soviet Union, North Africa and North America. VLPs from two of these cases were studied in detail and were shown to react specifically with antibody in acute phase sera obtained from other cases of ET-NA...

In order to study the clinical picture of non A, non B hepatitis in the elderly, a retrospective study was carried out in the two main hospitals in Jerusalem. Thirty-six patients with acute viral hepatitis, older than 65, have been hospitalized between the years 1982-1988. Seventy-two percent were diagnosed as non A, non B hepatitis. All patients were symptomatic and the main symptoms were abdo...

Background: Hepatitis viruses are non-cytopathic viruses that lead to the infection and pathogenesis of liver diseases as a result of immunologically mediated event. Objective: To investigate the expression of human inflammatory cytokines in chronic hepatitis B patients according to the severity of the infection. Methods: We recruited a total of 120 patients, 40 of whom from cirrhotic, 40 non-c...