نتایج جستجو برای: b ketoacyl coa synthase

تعداد نتایج: 993892  

Journal: :American journal of physiology. Endocrinology and metabolism 2002
Susanne Neschen Irene Moore Werner Regittnig Chun Li Yu Yanlin Wang Marc Pypaert Kitt Falk Petersen Gerald I Shulman

To examine the mechanism by which fish oil protects against fat-induced insulin resistance, we studied the effects of control, fish oil, and safflower oil diets on peroxisomal content, fatty acyl-CoA, diacylglycerol, and ceramide content in rat liver and muscle. We found that, in contrast to control and safflower oil-fed rats, fish oil feeding induced a 150% increase in the abundance of peroxis...

Journal: :The Journal of biological chemistry 2006
Shilpi Paul Kenneth Gable Frédéric Beaudoin Edgar Cahoon Jan Jaworski Johnathan A Napier Teresa M Dunn

Several 3-keto-synthases have been studied, including the soluble fatty acid synthases, those involved in polyketide synthesis, and the FAE1-like 3-ketoacyl-CoA synthases. All of these condensing enzymes have a common ancestor and an enzymatic mechanism that involves a catalytic triad consisting of Cys, His, and His/Asn. In contrast to the FAE1-like family of enzymes that mediate plant microsom...

Journal: :Cell structure and function 1992
N Kamasawa N Naito T Kurihara Y Kamada M Ueda A Tanaka M Osumi

The location of acetoacetyl-CoA thiolase (T-I) and 3-ketoacyl-CoA thiolase (T-III), enzymes of the fatty acid beta-oxidation system, was studied in n-alkane-grown Candida tropicalis cells by immunoelectron microscopy using a post-embedding method with colloidal gold conjugated IgG. The deposition of gold particles for T-I was detected in the microbodies and cytoplasm and that of gold particles ...

Journal: :The Biochemical journal 1986
M Servouse F Karst

In order to determine the regulation mechanisms of ergosterol biosynthesis in yeast, we developed growth conditions leading to high or limiting ergosterol levels in wild type and sterol-auxotrophic mutant strains. An excess of sterol is obtained in anaerobic sterol-supplemented cultures of mutant and wild type strains. A low sterol level is obtained in aerobic growth conditions in mutant strain...

Journal: :Biochemistry 2005
Jiamin Tian Anthony J Sinskey JoAnne Stubbe

Polyhydroxybutyrate (PHB) synthase catalyzes the polymerization of (R)-3-hydroxybutyryl-CoA (CoA = coenzyme A) into high molecular weight PHB. Recombinant wild-type (wt) class III synthase from Allochromatium vinosum (PhaCPhaE(Av)), antibodies to this synthase and to PHB, and [(14)C]hydroxybutyryl-CoA (HB-CoA) have been used to detect oligomeric hydroxybutyrate (HB) units covalently bound to th...

Journal: :Nucleic acids research 1990
J Ayté G Gil-Gómez F G Hegardt

The screening of a rat liver cDNA library with a hamster probe ACKNOWLEDGEMENTS that encompasses the nucleotides coding for the hamster enzyme . . . c . n T n w *~< J W C c A, , , • ,A A TAXI A A . U . 1 We are grateful to Drs. J.D.McGarry and V.Esser for providing (1), yielded a cDNA encoding the rat cytosolic ° yu 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase. t h e r a t h v e r c...

Journal: :Biochemical Society transactions 1997
R W Brownsey R Zhande A N Boone

Acetyl-CoA carboxylase (ACC; EC 6.4.1.2) catalyses the formation of malonyl-CoA, which is essential as a metabolic substrate and as a modulator of specific protein activity. Malonyl-CoA is a substrate for fatty acid synthase (FAS), for polyketide synthases (in plants, fungi and bacteria) and for fatty acyl chain-elongation systems. As an allosteric modulator, malonyl-CoA potently inhibits carni...

Journal: :The Biochemical journal 2005
Catherine Le Jossic-Corcos Céline Gonthier Isabelle Zaghini Emmanuelle Logette Ishaiahu Shechter Paulette Bournot

Dietary vegetable oils and fish oils rich in PUFA (polyunsaturated fatty acids) exert hypocholesterolaemic and hypotriglyceridaemic effects in rodents. The plasma cholesterol-lowering properties of PUFA are due partly to a diminution of cholesterol synthesis and of the activity of the rate-limiting enzyme HMG-CoA reductase (3-hydroxy-3-methylglutaryl-CoA reductase). To better understand the mec...

Journal: :The Biochemical journal 1992
O Ploux P Soularue A Marquet R Gloeckler Y Lemoine

The pimeloyl-CoA synthase from Bacillus sphaericus has been purified to homogeneity from an overproducing strain of Escherichia coli. The purification yielded milligram quantities of the synthase with a specific activity of 1 unit/mg of protein. Analysis of the products showed that this enzyme catalysed the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP. ...

2016
Katherine A Abrahams Chun-Wa Chung Sonja Ghidelli-Disse Joaquín Rullas María José Rebollo-López Sudagar S Gurcha Jonathan A G Cox Alfonso Mendoza Elena Jiménez-Navarro María Santos Martínez-Martínez Margarete Neu Anthony Shillings Paul Homes Argyrides Argyrou Ruth Casanueva Nicholas J Loman Patrick J Moynihan Joël Lelièvre Carolyn Selenski Matthew Axtman Laurent Kremer Marcus Bantscheff Iñigo Angulo-Barturen Mónica Cacho Izquierdo Nicholas C Cammack Gerard Drewes Lluis Ballell David Barros Gurdyal S Besra Robert H Bates

Phenotypic screens for bactericidal compounds are starting to yield promising hits against tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants generated against an indazole sulfonamide (GSK3011724A) identifies several specific single-nucleotide polymorphisms in the essential Mycobacterium tuberculosis β-ketoacyl synthase (kas) A gene. Here, this genomic-based ...

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