نتایج جستجو برای: azoles resistant
تعداد نتایج: 193707 فیلتر نتایج به سال:
Four sequential Aspergillus fumigatus isolates from a patient with chronic granulomatous disease (CGD) eventually failing azole-echinocandin combination therapy were investigated. The first two isolates (1 and 2) were susceptible to antifungal azoles, but increased itraconazole, voriconazole and posaconazole MICs were found for the last two isolates (3 and 4). Microsatellite typing showed that ...
Nine Candida strains (one C. dublinienses , six Candida albicans, two C. tropicalis, and one C. krusei ) isolated from human genital specimens were characterized based on their susceptibility to amphotericin B and imidazole (done by an adaptation of the National Clinical Laboratory Standards Broth Macrodilution method). All the nine strains were susceptible to amphotericin B with minimum inhibi...
The spectrum of invasive fungal infections (IFIs) continues to evolve with the emergence of rare and resistant fungal pathogens. Clinicians are faced with difficult diagnostic and treatment challenges in the management of immunocompromised patients at high risk of developing IFIs. Early and appropriate antifungal therapy is essential for a successful outcome when treating invasive mycoses. The ...
In the past decade, the frequency of opportunistic fungal infections has increased, and the spectrum of fungal pathogens has changed. The increasing number of susceptible hosts, the introduction of newer modalities for hematopoietic stem cell transplantation, the evolution of organ transplantation practices, the use of novel immunosuppressive agents, and current antimicrobial prophylactic strat...
OBJECTIVES In this study we investigated the in vitro fungistatic and fungicidal activities of CPA18 and CPA109, two azole compounds with original structural features, alone and in combination with fluconazole against fluconazole-susceptible and -resistant Candida albicans strains. METHODS Antifungal activities were measured by MIC evaluation and time-kill studies. Azole binding analysis was ...
In the pathogenic yeast Candida albicans, the zinc cluster transcription factor Upc2p has been shown to regulate the expression of ERG11 and other genes involved in ergosterol biosynthesis upon exposure to azole antifungals. ERG11 encodes lanosterol demethylase, the target enzyme of this antifungal class. Overexpression of UPC2 reduces azole susceptibility, whereas its disruption results in hyp...
We collected 1,486 clinical isolates of Candida species over a five-year period (2001 to 2005) in Japan and examined their species distribution and patterns of susceptibility to three antifungal azoles (fluconazole, itraconazole, and voriconazole). The most frequently isolated species was C. albicans, being followed by C. glabrata, C. tropicalis, C. parapsilosis and C. krusei, in this order, at...
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