PURPOSE To quantify microstructural abnormalities in the major association pathways of children affected by spina bifida myelomeningocele (SBM) and shunted hydrocephalus using whole-brain diffusion tensor imaging (DTI). MATERIALS AND METHODS The institutional review board approved this Health Insurance Portability and Accountability Act (HIPAA)-compliant study and written informed consent/ass...

BACKGROUND The aim of this study was to determine whether the diffusion tensor-derived radial diffusivity and axial diffusivity, measured in the cortico-spinal tract in the cervical cord, predict clinical recovery after a cord relapse in patients with multiple sclerosis, and change over time. METHODS Fourteen patients were clinically assessed at the onset of a cervical cord relapse and after ...

Fractional anisotropy (FA) is an effective marker of motor outcome at the chronic stage of stroke yet proves to be less efficient at early time points. This study aims to determine which diffusion metric in which location is the best marker of long-term stroke outcome after thrombolysis with diffusion tensor imaging (DTI) at 24 hours post-stroke. Twenty-eight thrombolyzed patients underwent DTI...

Increased production of industrial devices constructed with nanostructured materials raises the possibility of environmental and occupational human exposure with consequent adverse health effects. Ultrafine (nano) particles are suspected of having increased toxicity due to their size characteristics that serve as carrier transports. For this reason, it is critical to refine and improve existing...

The objective of this investigation was to determine whether there is mediated transport of endogenous proteins across the nuclear envelope. For this purpose, we studied the nuclear uptake of a 148,000-dalton Rana oocyte polypeptide (RN1) and compared its actual uptake rate with the rate that would be expected if RN1 crossed the envelope by simple diffusion through the nuclear pores. Nuclear up...

2. Analytical description of dipolar couplings in terms of molecular structure and dynamics . . . . . . . . . . . . . . . . . . 25 2.1. Incomplete averaging of the dipolar interaction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 2.2. Structural dependence of residual dipolar couplings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

Published by: Tehran University of Medical Sciences (http://ijp.tums.ac.ir) Fig. 1: Brain MRIs demonstrating hyperintense lesions in middle cerebellar peduncles on axial T2 weighted brain MRI (Part A), similar intensities in the tectum and tegmentum of midbrain on the left side (Part B), intense enhancement of mammillary bodies on the T1 weighted MRI with contrast (Part C), and hyperintense les...

We applied a single-shot echo-planar axial diffusion tensor sequence with parallel imaging for tractography of the cervical cord. Placing a large region of interest on a reconstructed sagittal image, the cervical cord was depicted as a tract bundle showing color-encoded cephalocaudally. By setting one region of interest in the cerebral peduncle and another in the entire cord on source images, t...

Fig. 1. MR imaging in the first 24 h after acute ipoxic–ischaemic brain damage. Axial apparent diffusion coefficient map shows a reduced ADC value (0.41) in posterior putamen and globus pallidus, and a high ADC value in anterior putamen and head of caudate nuclei (0.73), indicating the prevalence of T2 effect. The relatively high ADC value indicates chronic impairment of anterior portion of bas...

The physicochemical properties of bovine prothrombin and of bovine thrombin were previously described in this journal (1, 2). A derivative of bovine prothrombin, autoprothrombin II, has now been obtained in sufficient quality and quantity for study. In this report we describe some of the physicochemical properties of our product, including sedimentation coefficient, diffusion coefficient, intri...