With the spread of deadly diseases worldwide, design rapid tests to identify causative microorganisms is necessary. Due unique properties gold nanoparticles, these nanoparticles are used in designing diagnostic tests, such as strip tests. The current study aimed investigate ability bind single-chain variable fragment antibodies. In this study, biological and chemical methods included Escherichi...

Metal/alloy matrices have been previously reinforced with ceramic nanoparticles, but such reinforcements tend to agglomerate, weak interfaces, and are expensive. Polymer-derived ceramics (PDCs) based composites can potentially overcome these shortcomings. These obtained from the preceramic polymers after pyrolysis. inexpensive, be fragmented nanoscale, pyrolyzed in-situ. Friction stir processin...

Fragment-based drug discovery (FBDD) is complementary to high-throughput screening. The approach has two key stages: identifying the starting fragment hit to be developed and generating the lead compound from the starting fragment hit. Here, we provide an overview of FBDD and introduce two indices originally developed at Astellas Pharma. The first is related to the size ratio of fragment hits t...

A tryptic fragment (A) of Mr 25000 was prepared from bovine secretory component. The fragment binds polymeric immunoglobulin, although 9 times less effectively than secretory component on a molar basis. The fragment has four buried half-cystine residues and two exposed half-cystine residues. It gives rise to two fragments of Mr 11000-13000 on prolonged digestion with trypsin, and these do not b...

In two-dimensional denaturing gradient gel electrophoresis, DNA is digested with a restriction endonuclease and the resulting DNA fragments are separated as a function of size by conventional agarose gel electrophoresis. Following this first dimension electrophoresis, the fragment distribution is placed at the top of a denaturing gradient slab gel and electrophoresis is carried out parallel to ...

Two analytical mechanics-based models of dynamic fragmentation in brittle materials are proposed and solved to predict fragment size and time to fragmentation onset in terms of fundamental material properties and the applied strain rate. Previous widely-adopted analytical models of dynamic fragmentation are based on relatively simple energy balance arguments, and assume that the fragmentation e...

A formula for the fission fragment yield area in the coordinate system of the fragment total kinetic energy and of the fragment mass is presented. It was deduced along the lines of the multiexit-channel model of fission elaborated by Brosa, Grossmann and Müller. This formula was fitted to the fragment mass-, average total kinetic energy-, and variance distributions of the thermal neutron induce...

Studying the dynamic properties of rocks in complex environments is great significance to sustainable development deep-sea metal mineral resource extraction. To investigate influence dry–wet cycles on tensile and energy dissipation red sandstone, a series Brazilian disc tests was carried out through split Hopkinson pressure bar (SHPB) apparatus. The behaviors distribution sandstone specimens af...

From July 1989 to April 1993, Extracorporeal Shockwave Lithotripsy (ESWL) was performed on 642 patients, of which 21 were from the pediatric age group. All treatments were done on a second generation lithotriptor-Siemens Lithostar, which does not require any modification for positioning of children. Fragmentation was achieved in all the patients (100%). A complete stone free rate was achieved i...

Baseline event building and Level 3 trigger processing at the CDF experiment at Fermilab is speciied to process about 300 events/s with an average event size of about 150 KB. First, the event must be assembled from fragments originating from approximately 16 readout sources, with individual average fragment sizes ranging from 12 to 16 KB. Then the Level 3 processor-based trigger performs recons...