Autoinflammatory diseases area group of clinical conditions other than autoimmune diseases, characterized by recurrent inflammatory episodes. From apathogenetic point of view they are determined by a dys regulation of innate immunity, without involvement of specific immunity (auto reactive T cells and auto antibodies). Recently, the increased knowledge in the field of auto inflammation highligh...

BACKGROUND Adolescents with severe allergies are at particular risk of severe and fatal anaphylactic reactions. Epinephrine (adrenaline) is known to be under-utilized by teenagers. OBJECTIVE We sought to gain knowledge of adolescents' attitudes towards and experience of epinephrine auto-injectors in order to inform improvements in patient education. METHODS A qualitative study of adolescent...

BACKGROUND In view of the increasing prevalence of food allergies, there has been an associated increase in frequency of situations requiring an emergency response for anaphylaxis at the home, childcare facilities and educational institutions. OBJECTIVE To clarify the situation of adrenaline auto-injector administration in nursery/kindergarten/school, we carried out a questionnaire survey on ...

Malignant melanoma is one of the most aggressive types of tumor. Because malignant melanoma is difficult to treat once it has metastasized, early detection and treatment are essential. The search for reliable biomarkers of early-stage melanoma, therefore, has received much attention. By using a novel method of screening tumor antigens and their auto-antibodies, we identified bullous pemphigoid ...

In information retrieval, query auto completion (QAC), also known as typeahead [Xiao et al., 2013, Cai et al., 2014b] and auto-complete suggestion [Jain and Mishne, 2010], refers to the following functionality: given a prefix consisting of a number of characters entered into a search box, the user interface proposes alternative ways of extending the prefix to a full query. Ranking query complet...

In the temperature range of 10 to 80 ºC and in a batch digester, a typical activated sludge was digested aerobically. Reaction rate constants were determined by measuring the amounts of volatiles removed from the suspended solids at different time intervals during the process. The maximum value of the reaction rate constant (0.45 d-1) occurred in the temperature...

Bullous pemphigoid is a subepidermal blistering disease associated with auto-antibodies (auto-ab) to BP180 and BP230. We developed ELISAs utilizing baculovirus-encoded recombinant proteins of BP230 and BP180 and studied their diagnostic and prognostic values by assessing the profile of the auto-ab response in 127 patients with BP. 39 patients had focal involvement, whereas 88 had generalized di...

The effectiveness of microwave-assisted protein digestion in different well positions of a 96-well microplate was investigated where microwave-assisted protein digestion of bovine serum albumin was performed in 10 different wells of a 96-well microplate in a microwave oven. Similarly increased sequence coverages (~70%) were generally observed for the 10 microwaveassisted protein digestion sampl...

The continuing evolution of Graphics Processing Units (GPU) has shown rapid performance increases over the years. But with each new hardware generation, the constraints for programming them efficiently have changed. Programs have to be tuned towards one specific hardware to unleash the full potential. This is time consuming and costly as vendors tend to release a new generation every 18 months....