Abstract: Introduction: Periplaneta americana (P. americana), commonly known as the American cockroach, has shown multiple clinical benefits. Small Peptides from P. (SPPA) was found to have promising antioxidative effects in vitro. However, pharmacological benefits of SPPA demand further in-depth investigation underlying mechanism for its effect remain unexplored. Objectives: To evaluate on ova...

BACKGROUND Silent information regulator 2 related enzyme 1 (SIRT1) is one of the key factors in the mechanism of calorie restriction (CR) extending lifespan of animals. The aim of the study is to investigate if CR prolongs ovarian lifespan in mice through activating SIRT1 signaling. METHODS In the present study, 21 female C57BL/6 mice were divided into three groups: the control (n = 7), CR (n...

Ovarian follicular development in cattle is characterized by waves of growth during the prepubertal and postpartum periods and during estrous cycles. Each wave of follicular growth is characterized by recruitment of a cohort of follicles 4 to 5 mm in diameter. From the cohort, one follicle is selected for continued growth and becomes dominant. If luteolysis occurs during the growth phase of dom...

The regulation of insulin-like growth factor binding protein (IGFBP)-4 proteolytic degradation by insulin-like growth factors (IGFs) has been largely studied in vitro, but not in vivo. The aim of this study was to investigate the involvement of IGFs, IGFBP-2, IGFBP-3, and IGFBP-3 proteolytic fragments in the regulation of IGFBP-4 proteolytic activity in ovine ovarian follicles. Follicular fluid...

The aim of this study was to explore the real time changes in the vascularity of growing superovulated follicles and to establish whether the blood flow of growing follicles can affect superovulation variability. Eight Holstein-Freisian cows received PGF2α 10 days after spontaneous ovulation. After 36 hours, all follicles larger than 5 mm were aspirated at day 0 (D0). Animals were given 28 Armo...

FoxO1 is a transcription factor implicated in a growing number of physiological processes, including apoptosis, cell cycle progression, and insulin signaling. Recent findings indicate that FSH and growth factors influence ovarian functions in part through regulation of FoxO1. The present study utilized immunohistochemical analysis to determine the ovarian localization and regulation of FoxO1 pr...

erative disorder of unknown etiology and has threepathologic variants: hyaline-vascular (HV), plasma cell (PC), and mixed type [1]. Two clinically relevant subtypes exist, the unicentric and multicentric variants. Unicentric pancreatic Castleman’s disease is very rare with only 13 reported cases [2–14]. We report on the endosonographic features of pancreatic Castleman’s disease and its preopera...