OBJECTIVE This study was undertaken to compare the efficacy and tolerability of telmisartan, a novel antihypertensive agent, and atenolol, a well-established beta-blocker, in the treatment of mild to moderate hypertension. METHODS This 26-week, multicenter, randomized, double-blind, double-dummy, parallel-group, titration-to-response study compared doses of telmisartan (40 mg titrated to 80 m...

BACKGROUND Analyses of some randomised trials show that calcium-channel blockers reduce the risk of stroke more than expected on the basis of mean blood pressure alone and that beta blockers are less effective than expected. We aimed to investigate whether the effects of these drugs on variability in blood pressure might explain these disparities in effect on stroke risk. METHODS The Anglo-Sc...

It has been suggested that patients with essential hypertension may fall into three groups8: those with high renin levels, who respond best to beta-blockers; those with low renin levels, who respond best to diuretics; and those with normal renin, who respond equally to beta-blockers or diuretics. We could not identify any such subgroups in these few patients or any biochemical of physical marke...

OBJECTIVE To compare sotalol and atenolol in the treatment of symptomatic paroxysmal atrial fibrillation. DESIGN Prospective, randomised, open label, crossover study. SETTING University hospital. PATIENTS 47 subjects aged over 50 years were recruited from the hospital outpatient department following ECG documentation of paroxysmal atrial fibrillation that coincided with symptoms. Six pati...

The relative efficacy of nifedipine and slow-release nifedipine (Adalat Retard) in the treatment of stable exertional angina pectoris was evaluated in a double blind randomised crossover study in eight patients on no concomitant antianginal treatment and in 10 patients who were additionally on atenolol. Patients were assessed by angina diaries and exercise testing. Slow-release nifedipine was a...

Both atenolol and propranolol by mouth reduce ocular tension in normal and glaucomatous eyes (Phillips, Howitt, and Rowlands, i967; Elliot, Cullen, and Phillips, 1975; Wettrell and Pandolfi, 1975). These drugs are f-adrenergic blockers but propranolol affects both P1 and 32 receptors (as well as having a 'membrane' effect), while atenolol is a more specific 31 receptor antagonist and lacks the ...

A sensitive, accurate, precise and validated ion-pairing reverse-phase liquid chromatographic method for the quantitative determination of atenolol and indapamide in bulk and tablet dosage form was developed. The proposed ion-pairing reverse-phase high performance liquid chromatography method utilises C(18) column with 5 μm, 150×4.6 mm i.d. column and mobile phase consisting of 0.1% w/v solutio...

In a single-blind, randomised, crossover study in 10 asthmatic patients, the effects of approximately equipotent oral doses of 3 cardioselective beta-blockers-atenolol (100 mg), metoprolol (100 mg), and acebutolol (300 mg)-and 4 non-cardioselective beta-blockers-proranolol (100 mg), oxprenolol (100 mg), pindolol (5 mg), and timolol (10 mg) upon FEV1 were compared. All drugs, except pindolol, pr...