Studies have long reported that aging is associated with declines in several functions modulated by the prefrontal cortex, including executive functions like working memory, set shifting, and inhibitory control. The neurochemical basis to this is poorly understood, but may include the serotonergic system. We investigated the modulatory effect of serotonin using acute tryptophan depletion (ATD) ...

patients with turner’s syndrome (ts) are at an increased risk of developing autoimmune thyroid disease (atd). the aim of this study was to determine the frequency of anti-thyroid peroxidase (anti-tpo) antibodies and atd in children and adolescent girls with ts. it also assessed the influence of karyotype on the development of thyroid disease. sixty eight patients with ts were compared with 68 a...

A abordagem metodológica com histórias de vida tem sido utilizada na pesquisa educacional. Este estudo investiga como a Análise Textual Discursiva (ATD), desenvolvida por Morais e Galiazzi (2016), corrobora compreensão interpretação das dos sujeitos. Fez-se necessário caracterizar as etapas do ciclo análise da ATD, exemplificando-as dados mestrado (AUTOR, 2018). Direciona-se pela qualitativa. C...

Ionotropic glutamate receptors are functionally diverse but have a common architecture, including the 400-residue amino-terminal domain (ATD). We report a 1.8-A resolution crystal structure of human GluR2-ATD. This dimeric structure provides a mechanism for how the ATDs can drive receptor assembly and subtype-restricted composition. Lattice contacts in a 4.1-A resolution crystal form reveal a t...

AMPA subtype ionotropic glutamate receptors (iGluRs) mediate the majority of fast neurotransmission across excitatory synapses in the central nervous system. Each AMPA receptor is composed of four multi-domain subunits that are organized into layers of two amino-terminal domain (ATD) dimers, two ligand-binding domain (LBD) dimers, transmembrane domains and carboxy-terminal domains. We introduce...

Game theory has been useful for understanding risk-taking and cooperative behavior. In the present study, subjects played the Hawk-Dove game with simulated and embodied (robotic) neural agents which used a neurobiologically plausible model of action selection and adaptive behaviors. Subjects had their serotonin levels temporarily altered through acute tryptophan depletion (ATD). The traditional...

Ion conductivity and the gating characteristics of tetrameric glutamate receptor ion channels are determined by their subunit composition. Competitive homo- and hetero-dimerization of their amino-terminal domains (ATDs) is a key step controlling assembly. Here we measured systematically the thermodynamic stabilities of homodimers and heterodimers of kainate and AMPA receptors using fluorescence...

HyunWook Park, MEMBER SPIE Korea Advanced Institute of Science and Technology Department of Electrical Engineering 373-1 Guseong-dong Yuseong-gu Daejeon 305-701, Korea E-mail: [email protected] Abstract. This paper presents a new automatic target detection (ATD) algorithm to detect targets such as battle tanks and armored personal carriers in ground-to-ground scenarios. Whereas most ATD...

BACKGROUND Acute tryptophan depletion (ATD) is a well-established dietary method in translational brain research used to briefly lower central nervous serotonin (5-hydroxytryptamine (5-HT)) synthesis. A simplified two amino acid ATD formula (ATDPHE/LEU) was developed while reducing the overall amount of amino acids (AAs), with the objective of administration especially in children and adolescen...