نتایج جستجو برای: asthma exacerbation
تعداد نتایج: 77343 فیلتر نتایج به سال:
BACKGROUND The 72 kDa matrix metalloproteinase 2 (MMP-2) and the 92 kDa matrix metalloproteinase 9 (MMP-9) are type IV collagenases implicated in various aspects of inflammation including accumulation of inflammatory cells, tissue injury, and development of remodelling. The role of these enzymes in the pathogenesis of asthma exacerbations is unknown. METHODS Circulating levels of MMP-2 and MM...
We read with great interest the paper by Gelb and colleagues who suggest that peripheral airway/alveolar nitric oxide (NO) concentration after correction for axial NO back-diffusion (CalvNOcorrected) is normal during asthma exacerbation (with a hypothesis of an incidence of >30% of its increase). If one admits that an exacerbation constitutes the ultimate expression of loss of asthma control, t...
This article summarizes the recommendations regarding the management of asthma exacerbations presented in the Expert Panel Report 3 (EPR3). The evidence supporting these recommendations can be found in the report itself. All of the recommendations in this article are strong recommendations, unless indicated by the term conditional. Asthma exacerbations consist of acute or subacute episodes of p...
RATIONALE Heterogeneity in asthma expression is multidimensional, including variability in clinical, physiologic, and pathologic parameters. Classification requires consideration of these disparate domains in a unified model. OBJECTIVES To explore the application of a multivariate mathematical technique, k-means cluster analysis, for identifying distinct phenotypic groups. METHODS We perfor...
Background Psychological morbidity is associated with frequent asthma exacerbations, higher health care utilization, as well as near-fatal and fatal asthma. The prevalence of psychological comorbidities in patients with severe asthma is not well-studied. The aim of our study was to evaluate the prevalence of anxiety, depression and hyperventilation, and correlate these symptoms with asthma cont...
Asthma treatment response is ascertained by improvement in ≥1 key asthma outcome (exacerbations/symptom control/lung function). This post hoc analysis of LIBERTY ASTHMA QUEST (NCT02414854) assessed dupilumab effect patients with uncontrolled, moderate-to-severe using a multicomponent endpoint representing various dimensions clinical remission. Clinical remission components (no exacerbations/5-i...
Extrafine triple therapy and asthma exacerbation seasonality: TRIMARAN and TRIGGER post hoc analyses
BackgroundPrevious studies have shown seasonal variation in asthma exacerbations, peaking over the winter months. A single-inhaler triple therapy containing extrafine formulations of inhaled corticosteroid (ICS) beclomethasone dipropionate (BDP), long-acting β2-agonist formoterol fumarate (FF), and muscarinic antagonist glycopyrronium (G) is development for asthma.ObjectiveWe sought to evaluate...
RATIONALE Rhinoviruses are the major cause of asthma exacerbations; however, its underlying mechanisms are poorly understood. We hypothesized that the epithelial cell-derived cytokine IL-33 plays a central role in exacerbation pathogenesis through augmentation of type 2 inflammation. OBJECTIVES To assess whether rhinovirus induces a type 2 inflammatory response in asthma in vivo and to define...
Invasive pulmonary aspergillosis (IPA) is a severe fungal infection with a high mortality rate. The incidence of IPA is on the rise due to an increase in the number of patients undergoing transplants and receiving chemotherapy and immunosuppressive therapy. Diagnosis is challenging due to the non-specific nature of symptoms. Voriconazole is the mainstay of therapy. We present a case of an elder...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید