2-Mercaptoethanol inhibits growth of Aspergillus parasiticus NRRL 3240 and aflatoxin formation by the fungus. When added to the resuspended medium, 2-mercaptoethanol inhibited [1-14C]acetate incorporation into both aflatoxins and neutral lipids, thereby showing that it acts at an early stage of aflatoxin biosynthesis. The inhibition is probably due to its chelating action on zinc, which is esse...

From April 2003 to September 2004, 59 ears from 55 patients received suction clearance and topical miconazole 2% (regimen 1) and in September 2004 to December 2005, 64 ears from 58 patients received the same combinations plus acidic drops [acetic acid 3% (v/ v) in 97% ethanol]. The mean age of patients treated with regimen 1 was 35.76+/-16 years and in regimen 2 was 37.98+/-15 years. Aspergilus...

Aflatoxins (AFs) belong to a closely related group of secondary fungal metabolites. These mycotoxins are severely toxic metabolites produced mainly by Aspergillus flavus and A. parasiticus, and exposure to them can cause cancer in humans and livestock [1]. Based on epidemiological evidence, AFs have been classified as human liver carcinogens by the World Health Organization and by the U.S. Envi...

Aflatoxicosis has been associated with primary hepatocellular cancer, infertility, malnutrition and growth retardation. It is a commonly seen in areas where maize and groundnuts are contaminated by the Aspergillus flavus and A. parasiticus. These fungi grow in hot and humid environments and poor drying of cereals. The fungal agents produce mycotoxins, principally, aflatoxins AFB1, AFG1, AFB2 an...

Objective(s): The enzymatic activity of fungi has recently inspired the scientists with re-explore the fungi as potential biofactories rather than the causing agents of humans and plants infections. In very recent years, fungi are considered as worthy, applicable and available candidates for synthesis of smaller gold, silver and other nano-sized particles.  Materials and Methods: A standard str...

Pseudotutin previously isolated from Coriaria japonica A. GRAY was revealed to be a molecular compound consisting of equimolar tutin (2) and a new related sesquiterpene lactone, corianin (3). Corianin was also isolated together with coriamyrtin (1), tutin (2) and coriatin (4), from Loranthus parasiticus MERR., a parasitic plant that grows on the twigs of Coriaria sinica MAXIM. The structure of ...

background: aflatoxins are toxic fungal metabolites enable to contaminate a wide range of natural substrates. this contamination can be host-specific for different plant species. in this study, the ability of a toxigenic aspergillus parasiticus to produce various aflatoxins on major iranian cereals was evaluated with special focus on plant susceptibility to toxin production at cultivar level. m...

background: the effect of curcumin as a natural safe compound with different biological activities was examined on fungal growth and aflatoxin production in aspergillus parasiticus nrrl 2999. methods: the fungus was cultured in presence of serial two-fold concentrations of curcumin (125-2000 µg/ml) in yeast extract sucrose broth for 3 days at 28°c. mycelia dry weight was determined as an index ...