Yeehaw! The rotation of a visible-light-driven molecular motor based on barbituric acid is tamed by hydrogen bonding “lasso” mechanism between its serendipitously-formed tertiary hydroxy stereocentre and lower half carbonyl groups.

The studies on design and synthesis of new monocyclic β-lactam esters 4(R/S)-(1'-methoxycarbonylpropyl2'(R/S)-thio)-3(R)-phenylacetamidoazetidin-2-one (3a) and 4(R/S)-(1'-methoxycarbonyl-2'-methyl-propyl-2'thio)-3(R)-phenylacetamidoazetidin-2-one (3b) were described. Compounds 3a and 3b were specifically designed to retain all penicillin substructures except the bicyclic system, which would be ...

Several nitrogen-containing dietary supplements were fed to chicks to study their effects on growth and tissue nitrogen products. An antibiotic mixture was added to the diet to determine its effect on the metabolism of nitrogenous compounds. In the first experiment, 2.0% protein equivalent was added as diammonium citrate (DAC) or isolated soy protein (ISP) to a balanced practical diet. DAC lowe...

At concentrations that produce anesthesia, many barbituric acid derivatives act as positive allosteric modulators of inhibitory GABAA receptors (GABAARs) and inhibitors of excitatory nicotinic acetylcholine receptors (nAChRs). Recent research on [H]R-mTFD-MPAB ([H]R-5-allyl-1-methyl-5-(m-trifluoromethyldiazirinylphenyl)barbituric acid), a photoreactive barbiturate that is a potent and stereosel...

3-methyl-1-sulfonic acid imidazolium tetrachloroferrate {[Msim]FeCl4} as an efficient sulfur catalyst was prepared and applied, as an efficient catalyst, for the cross-aldol condensation reaction between cycloalkanones and arylaldehydes to give α,αʹ- bis(arylidene)cycloalkanones in high yields and short reaction times at 75 °C under solvent-free conditions. 3-methyl-1-sulfonic acid imidazolium...

Z. Naturforsch. 51 b, 409-416 (1996); eingegangen am 28. Juni 1995 Reduction, Narthigenine, Butyrolactones, Butyrolactams, Tetramic Acids A series of potentially cytotoxic a,/?-unsaturated 7 -hydroxy-butyrolactones, -lactams and -thiolactones has been synthesized via regioselective hydride reduction of the appropriate maleic acid anhydrides, imides and thioanhydrides. By this means a straightfo...

At concentrations that produce anesthesia, many barbituric acid derivatives act as positive allosteric modulators of inhibitory GABAA receptors (GABAARs) and inhibitors of excitatory nicotinic acetylcholine receptors (nAChRs). Recent research on [H]R-mTFD-MPAB ([H]R-5-allyl-1-methyl-5-(m-trifluoromethyldiazirinylphenyl)barbituric acid), a photoreactive barbiturate that is a potent and stereosel...

At concentrations that produce anesthesia, many barbituric acid derivatives act as positive allosteric modulators of inhibitory GABAA receptors (GABAARs) and inhibitors of excitatory nicotinic acetylcholine receptors (nAChRs). Recent research on [(3)H]R-mTFD-MPAB ([(3)H]R-5-allyl-1-methyl-5-(m-trifluoromethyldiazirinylphenyl)barbituric acid), a photoreactive barbiturate that is a potent and ste...

Three novel colorimetric methods of detecting urinary nicotine metabolites called the barbituric acid, diethylthiobarbituric acid (DETB), and DETB extraction methods were evaluated for use as a simple, cheap, objective test of smoking. Urine samples were collected from 103 male smokers and 78 male non-smokers working at two London factories. The smokers recorded the number of cigarettes smoked ...