6-carbethoxy-5-(3'-bromophenyl)-3-aryl-2-cyclohexenones 2a-j were obtained from the1-aryl-3-(3'-bromophenyl)-2-propene-1-ones 1a-j by micheal addition of ethyl acetoacetate, followed by internal claisen condensation. reaction of 2a-j with hydrazine hydrate afforded the corresponding 6-aryl-4-(3'-bromophenyl)-3-oxo-2,3a,4,5-tetrahydro-2h-indazoles 3a-j. the structures of newly syn...

cellulose was applied as a reusable and green catalyst for the facile four-component synthesis of 6-amino-4-aryl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives using hydrazine monohydrate, ethyl acetoacetate, malononitrile and aryl aldehydes, under solvent-free and thermal conditions. the use of non-toxic and inexpensive catalyst, short reaction time, clean work-up and goo...

Aldehyde dextran sulfonate (ADS), a modified oligosaccharide polymer, was used to prepare a new matrix structure for affinity biosensors. The principal difference between the ADS matrix and similar structures developed previously results from presence of two active functional groups in the matrix, namely, aldehyde and sulfonate. These groups perform two different functions in the matrix. The al...

The biaryl structural motif is a predominant feature in many pharmaceutically relevant and biologically active compounds. As a result, for over a century1 organic chemists have sought to develop new and more efficient aryl-aryl bond-forming methods. Although there exist a variety of routes for the construction of aryl-aryl bonds, arguably the most common method is through the use of transition-...

in the present study, aminoazines were prepared from the reaction of amidrazone hydroiodide with various aromatic aldehydes in the presence of a solid base under microwave irradiation with power level of 850 w for 2-7 min in high yields. the amidrazone hydroiodide can also be prepared by the reaction of s-methyl isothiobenzamide hydroiodide and hydrazine in methanol under nitrogen gas. all synt...

Aldehyde oxidases are molybdo-flavoenzymes structurally related to xanthine oxidoreductase. They catalyze the oxidation of aldehydes or N-heterocycles of physiological, pharmacological, and toxicological relevance. Rodents are characterized by four aldehyde oxidases as follows: AOX1 and aldehyde oxidase homologs 1-3 (AOH1, AOH2, and AOH3). Humans synthesize a single functional aldehyde oxidase,...

The preand post-natal ontogeny of Sprague-Dawley rat liver aldehyde dehydrogenase [aldehyde-NAD(P)+ oxidoreductase, EC 1.2.1.5] is described. At no time in its ontogenetic development does normal liver aldehyde dehydrogenase exhibit any of the characteristics of a series of unique aldehyde dehydrogenases that can be isolated from 2-acetamidofluorene-induced rat hepatomas. Enzyme activity is fir...