BACKGROUND Adverse effects of anticholinergic medications may contribute to events such as falls, delirium, and cognitive impairment in older patients. To further assess this risk, we developed the Anticholinergic Risk Scale (ARS), a ranked categorical list of commonly prescribed medications with anticholinergic potential. The objective of this study was to determine if the ARS score could be u...

Adrenergic receptors (AR) are G-protein-coupled receptors (GPCRs) that have a crucial role in cardiac physiology in health and disease. Alpha1-ARs signal through Gαq, and signaling through Gq, for example, by endothelin and angiotensin receptors, is thought to be detrimental to the heart. In contrast, cardiac alpha1-ARs mediate important protective and adaptive functions in the heart, although ...

The antisynthetase syndrome (ASS) was first described by Marguerie and coworkers in 1990 as a triad of polymyositis, diffuse interstitial lung disease (ILD) and serum autoantibodies to aminoacyl transfer RNA synthetases (anti-ARS) (1). Later, cohort studies have indicated that 20-25 % of patients diagnosed with polymyositis (PM) or dermatomyositis (DM) have antiARS antibodies (2-4). In most cas...

Adaptive Random Searches (ARS) are simple and effective optimization methods used for handling complicated nonconvex / multimodal nonlinear programming (NLP) and mixed-integer nonlinear programming (MINLP) problems. ARS iteratively adapt search characteristics according to the past successful / failure steps. Periodic search domain expansions and contractions improve significantly the reliabili...

In several complex applications, the use of multiple autonomous robotic systems (ARS) becomes necessary to achieve different tasks, such as foraging and transport of heavy and large objects, with less cost and more efficiency. They have to achieve a high level of flexibility, adaptability and efficiency in real environments. In this paper, a reinforcement learning (RL)-based group navigation ap...

Patients with high FLT3 internal tandem duplication allelic ratios (FLT3/ITD-ARs) have a poor prognosis. Single-nucleotide polymorphism/comparative genomic hybridization, single-cell PCR and colony-forming assays were used to evaluate genotypic evolution of high FLT3/ITD-ARs in 85 acute myeloid leukemia (AML) patients. Microarrays were used to examine molecular pathways disrupted in leukemic bl...

The interactions of an anionic redox-active dye Alizarin Red S (ARS) with novel N-hydroxyethyl-3-alkyloxypyridinium surfactants 1-(2-hydroxyethyl)-3-(tetradecyloxy)pyridinium bromide, [HEC14OPyBr], and 1-(2-hydroxyethyl)-3-(hexadecyloxy)pyridinium bromide, [HEC16OPyBr], were investigated in an aqueous solution for the first time with an attempt to obtain comprehensive knowledge of oppositely ch...

Alternative RNA structures (ARSs), or alternative transcript isoforms, are critical for regulating cellular phenotypes in humans. In addition to generating functionally diverse protein isoforms from a single gene, ARS can alter the sequence contents of 5'/3' untranslated regions (UTRs) and intronic regions, thus also affecting the regulatory effects of these regions. ARS may introduce premature...

PURPOSE The homeobox transcription factor PITX2 is a known regulator of mammalian ocular development, and human PITX2 mutations are associated with Axenfeld-Rieger syndrome (ARS). However, the treatment of patients with ARS remains mostly supportive and palliative. METHODS The authors used molecular genetic, pharmacologic, and embryologic techniques to study the biology of ARS in a zebrafish ...

Axenfeld-Rieger syndrome (ARS) is a rare autosomal dominant inherited disorder affecting the development of the eyes, teeth and abdomen. The syndrome is characterised by complete penetrance but variable expressivity. The ocular component of the ARS phenotype has acquired most clinical attention and has been dissected into a spectrum of developmental eye disorders, of which open-angle glaucoma r...