Tuberculosis (TB) is the oldest documented infectious disease. Fragments of the spinal column from Egyptian mummies from 2400 B.C. shows definite pathological signs of tubercular decay. The term phthisis (consumption) appears first in Greek literature. Hypocrates identified phthisis as the most widespread disease of the times around 460 B.C. Exact pathological and anatomical descriptions of the...

Inhibition of renin was induced in conscious marmosets with CGP 29 287, Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys (Boc)-OMe, a renin inhibitor with a prolonged duration of action. In vitro, CGP 29 287 is a potent inhibitor of primate plasma renin (inhibitory concentration, 50%: human = 1 X 10(-9) M; marmoset = 5 X 10(-9) M) and less potent against dog (2 X 10(-7) M) or rat (3 X 10(-5) M) plasma ren...

Pdr5p, the major multidrug exporter in Saccharomyces cerevisiae, is a member of the ATP-binding cassette (ABC) superfamily. Pdr5p shares similar mechanisms of substrate recognition and transport with the human MDR1-Pgp, despite an inverted topology of transmembrane and ATP-binding domains. The hexahistidine-tagged Pdr5p multidrug transporter was highly overexpressed in yeast strains where other...

Bending of purple membranes in dependence on the pH analyzed by AFM and single molecule force spectroscopy R.-P. Baumann, M. Schranz and N. Hampp, Phys. Chem. Chem. Phys., 2010 DOI: 10.1039/b919729j Bifunctional polyacrylamide based polymers for the specific binding of hexahistidine tagged proteins on gold surfaces Lucas B. Thompson, Nathan H. Mack and Ralph G. Nuzzo, Phys. Chem. Chem. Phys., 2...

“death” as one of the basic subject and a fact is considered by all contemporary and previous poets and scholars. ghaddeh-samman, an arab poet and writer, was influenced by the defeat of arabs from israel in one hand, and because of his presence in lebanon since the civil war in the country was influenced by bad effects of the war in the other hand. thats why the word “death” overruled its imag...

bertolt brecht composed poems, focusing on the political, social and economic situations of his time. this fact could also be seen in his plays. with this outlook brecht challenges the readers of his work with regard to the social problems of their time. doing so, the reader finds himself in a difficult task that tests his ability and skill to resolve the problems. the initial poems of brecht s...