PURPOSE This report describes the development and preliminary analysis of a database for traumatically injured military service members with dysphagia. METHODS A multidimensional database was developed to capture clinical variables related to swallowing. Data were derived from clinical records and instrumental swallow studies, and ranged from demographics, injury characteristics, swallowing b...

OBJECTIVES This study examines the association of daily cortisol with depressive mood and anger. METHOD Depressive mood, anger and 2 markers of cortisol, area under the curve (AUC), and cortisol awakening response (CAR) were examined for caregivers (N = 164) of individuals with dementia (IWDs) across 8 days, some of which IWDs attended an adult day service (ADS) program. Caregivers were prima...

Diagnostic biomarkers are used frequently in epidemiologic and clinical work. The ability of a diagnostic biomarker to discriminate between subjects who develop disease (cases) and subjects who do not (controls) is often measured by the area under the receiver operating characteristic curve (AUC). The diagnostic biomarkers are usually measured with error. Ignoring measurement error can cause bi...

AIM To test the variability within and between subject of glycemic response test following the ingestion of a standard food. MATERIAL AND METHODS Glucose and insulin response of a standard meal (white bread) was performed in ten healthy volunteers and repeated under identical conditions for 6 times. Blood glucose and insulin levels were measured in the fasted state and over the 180 min follow...

The objective of this research was to examine whether the Holmes-Rahe Social Readjustment Rating Scale, a life event scale, can be used to identify suicide attempters. The Holmes-Rahe Social Readjustment Rating Scale's ability to identify suicide attempters was tested in 1183 subjects (478 suicide attempters, 197 psychiatric inpatients, and 508 healthy controls) using the Fisher Linear Discrimi...

PURPOSE To assess the predictive validity of frailty and its domains (physical, psychological, and social), as measured by the Tilburg Frailty Indicator (TFI), for the adverse outcomes disability, health care utilization, and quality of life. DESIGN AND METHODS The predictive validity of the TFI was tested in a representative sample of 484 community-dwelling persons aged 75 years and older in...

We examined the effects of ischemia (ISC) alone and with low-intensity exercise (ISC+EX) on growth hormone (GH) and muscle function responses. Nine men (22 +/- 0.7 yr) completed 3 study days: an ISC day (thigh cuff inflated five times, 5 min on, 3 min off), an ISC+EX day [knee extension at 20% maximal voluntary contraction (MVC) with ISC], and a control day. MVCs and submaximal contraction task...

The aim of the present study was to determine whether the residual area under the curve (AUC(res%); expressed as % of total value of AUC) could be used as a parameter for the qualitative evaluation of pharmacokinetic studies.We propose new criteria for the qualitative evaluation of pharmacokinetic analysis. Two sets of hypothetical data that illustrate the relationship between concentration and...

Results The study included a total of 334 women with mean age 57 ± 5 years. According to the 10-FRS and the WHOS, 96% and 91% of the population were respectively classified as “low risk”. A fair level of agreement between both scores was found (kappa 0.31). CAP occurred in 29% of cases. Score estimated risk correlated with CAP prevalence. Women with CAP presented higher incidence of hypertensio...

The postantifungal effect (PAFE) of amphotericin B was determined with a BacT/Alert automated system, which is based on the colorimetric detection of CO(2). The levels of accuracy and precision of the automated method were high. Longer PAFEs were obtained for Candida albicans (P < 0.001), C. glabrata (P < 0.01), and C. krusei (P < 0.01) at increasing amphotericin B concentrations and exposure t...