A 26-year-old, 17-week pregnant woman developed aquaporin-4-IgG-positive severe longitudinally extensive transverse myelitis during the course of disseminated herpes zoster and became quadriparetic. She was unresponsive to high-dose intravenous methylprednisolone but became able to walk without assistance after intravenous immunoglobulin. One and a half months later, left optic neuritis develop...

Aquaporin attracted attention not only of physiologists and biophysicists, but also of chemical engineers. Here we critically analyze a paper describing aquaporin-based artificial membranes, suggested for forward osmosis-based water purification (Wang et al. 2012, Small 8, pp. 1185-1190). Related papers published later by the same group are also discussed. We indicate recently developed general...

Aquaporins are a family of ubiquitous membrane proteins that form a pore for the permeation of water. Both electron and X-ray crystallography played major roles in determining the atomic structures of a number of aquaporins. This review focuses on electron crystallography, and its contribution to the field of aquaporin biology. We briefly discuss electron crystallography and the two-dimensional...

Acetazolamide (AZA) reduces the water permeability of aquaporin-4, the predominant water channel in the brain. We determined the structure of aquaporin-4 in the presence of AZA using electron crystallography. Most of the features of the 5-Å density map were consistent with those of the previously determined atomic model. The map showed a protruding density from near the extracellular pore entra...

Aquaporins, also known as water channels, are a large family of transmembrane channel proteins present throughout all life domains and implicated in human disorders. The psychrophilic aquaporin comes to attention because its specialty adaptive ability keep on functioning maintain homeostasis under low temperatures, which have an optimal temperature for growth at about 15ºC or lower. However, st...

Abstract Vasopressin-mediated water reabsorption from primary urine in the renal collecting duct is essential for regulating body homeostasis and depends on channel aquaporin-2 (AQP2). Dysregulation of process can cause balance disorders. Here, we present cell-based high-throughput screenings to identify proteins small molecules as tools elucidate molecular mechanisms underlying AQP2 control po...